The application of resonance light scattering technique for the determination of tinidazole in drugs.

Journal of Automated Methods & Management in Chemistry Pub Date : 2007-01-01 DOI:10.1155/2007/86857

Xin Yu Jiang, Xiao Qing Chen, Zheng Dong, Ming Xu

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引用次数: 17

Abstract

A resonance light scattering technique to determine tinidazole in drugs was developed by tetraphenylboron sodium (TPB). Tinidazole was found to bind B(C(6)H(5))(-) (4) anion and transformed to tinidazole-TPB aggregate which displayed intense resonance scattering light. Effects of factors such as wavelength, acidity, stabilizers, and interferents on the RLS of tinidazole TPB were investigated in detail. The RLS intensity of the tinidazole-TPB suspension was obtained in sulfuric acid solution (pH = 1.44). The resonance scattering light intensity at the maximum RLS peak of 569.5 nm was linear to the concentration of tinidazole in the range of 10.0-30.0 mug mL(-1) with a detection limit of 5.0 mug mL(-1). Good results were also obtained with the recovery range of 95.13-106.76%. The method was applied to determine tinidazole in injections and tablets, showing high sensitivity and accuracy compared with the high performance liquid chromatography method (HPLC) according to Chinese Pharmacopoeia.

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共振光散射技术在药物中替硝唑含量测定中的应用。

建立了用四苯硼钠(TPB)测定药物中替硝唑的共振光散射技术。发现替硝唑与B(C(6)H(5))(-)(4)阴离子结合，转化为替硝唑- tpb聚集体，表现出强烈的共振散射光。研究了波长、酸度、稳定剂、干扰剂等因素对替硝唑TPB RLS的影响。测定了替硝唑- tpb悬浮液在pH = 1.44的硫酸溶液中的RLS强度。最大RLS峰569.5 nm处的共振散射光强与替硝唑浓度在10.0 ~ 30.0马克mL(-1)范围内呈线性关系，检出限为5.0马克mL(-1)。回收率为95.13 ~ 106.76%，效果良好。该方法用于替硝唑注射液和片剂的含量测定，与《中国药典》规定的高效液相色谱法相比，具有较高的灵敏度和准确性。

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Journal of Automated Methods & Management in Chemistry 化学-分析化学

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>12 weeks