HLA-associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives.

V Guérin, L Léniaud, B Pédron, S Guilmin-Crépon, N Tubiana-Rufi, G Sterkers
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引用次数: 10

Abstract

The distribution of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1 haplotypes was analyzed separately in two distinct French ethnic groups with type I diabetes (T1D), i.e. French North African migrants (n= 64, mean age at diagnosis = 8.25 years) and ancient French natives (n= 60, mean age at diagnosis = 7.42 years). HLA associations were determined by calculating odds ratios (ORs) between patients and two ethnic-matched control populations. Results show highly similar ORs for the conservative DRB1*0301-DQA1*0501-DQB1*0201 haplotype of susceptibility (OR: 3.22 and 3.93 in migrants and natives, respectively) and the DRB1*1501-DQA1*0102-DQB1*0602 haplotype of resistance (OR: 0.05 and 0.03, respectively). In contrast, among the more variable DRB1*04-DQB1*0302 haplotypes of susceptibility, the DRB1*0402 (OR: 3.10 and 32.84) and 0405 (OR: 5.90 and 16.25, respectively) were associated with T1D in migrants and natives, whereas an increase of DRB1*0401, a rare allele in migrants, was significant in natives only. Also, among the DRB1*11-DQA1*0505-DQB1*0301 haplotypes of resistance, the OR observed for DRB1*1104-DQA1*0505-DQB1*0301, common in migrants, was lower (OR: 0.08) than for DRB1*1101-DQA1*0505-DQB1*0301 (OR: 0.32), common in natives. How DRB1*11 subtypes might affect differently the risk conferred by DQA1*0505-DQB1*0301 will be discussed.

法属北非人和法国本地人hla相关基因抵抗和1型糖尿病易感性
我们分别分析了2个不同的法国1型糖尿病(T1D)人群中人类白细胞抗原(HLA)-DRB1-DQA1-DQB1单倍型的分布,即法国北非移民(n= 64,平均诊断年龄为8.25岁)和古法国本地人(n= 60,平均诊断年龄为7.42岁)。通过计算患者和两个种族匹配的对照人群之间的优势比(ORs)来确定HLA相关性。结果表明,保守型DRB1*0301-DQA1*0501-DQB1*0201易感单倍型和抗性单倍型DRB1*1501-DQA1*0102-DQB1*0602易感单倍型的OR值(分别为3.22和3.93)非常相似(分别为0.05和0.03)。相比之下,在更易变的DRB1*04-DQB1*0302单倍型中,DRB1*0402 (OR分别为3.10和32.84)和0405 (OR分别为5.90和16.25)与移民和本地人的T1D相关,而DRB1*0401是移民中罕见的等位基因,仅在本地人中显著增加。在DRB1*11-DQA1*0505-DQB1*0301抗性单倍型中,迁移人群中常见的DRB1*1104-DQA1*0505-DQB1*0301的OR (OR: 0.08)低于本地人群中常见的DRB1*1101-DQA1*0505-DQB1*0301 (OR: 0.32)。将讨论DRB1*11亚型对DQA1*0505-DQB1*0301所赋予风险的不同影响。
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来源期刊
Tissue antigens
Tissue antigens 医学-病理学
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6 months
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