Immunosenescence: deficits in adaptive immunity in the elderly.

F T Hakim, R E Gress
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引用次数: 213

Abstract

Aging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age-associated immune dysfunctions are the consequence of declines in both the generation of new naïve T and B lymphocytes and the functional competence of memory populations. These alterations collectively are termed immunosenescence.

免疫衰老:老年人适应性免疫缺陷。
在临床上,衰老与传染病的频率和严重程度的增加以及癌症、慢性炎症性疾病和自身免疫的发病率增加有关。这些与年龄相关的免疫功能障碍是新生成naïve T淋巴细胞和B淋巴细胞以及记忆群体功能能力下降的结果。这些改变统称为免疫衰老。
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来源期刊
Tissue antigens
Tissue antigens 医学-病理学
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