[Expression of Endothelin-1 in laryngeal carcinoma].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Pub Date : 2006-12-01

Jian Zhang, Wei Zhong, Wugen Luo, Zhiyuan Zhang

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Abstract

Objective: To study the expression and clinical significance of Endothelin-1 in laryngeal carcinoma.

Method: Immunohistochemical (SP) method was used to detect the expression of Endothelin-1 in 30 cases of laryngeal carcinoma,20 cases of laryngeal benign lesions and 10 cases of. The relationship between the expression of Endothelin-1 and the clinic stage was analysed by SPSS12. 0 software. RESULT. The positive expression of Endothelin-1 in all three type tissues. There is a significant difference between the laryngeal carcinoma and the laryngeal benign lesions, the laryngeal carcinoma and the normal laryngeal mucous membrane, the laryngeal benign lesions and the normal laryngeal mucous membrane( P <0. 05). The highest expression of Endothelin-1 is in laryngeal carcinoma tissue. In laryngeal carcinoma tissue, the advanced clinical stage, the more higher expression of endothelin-1.

Conclusion: Positive expression of Endothelin-1 in laryngeal carcinoma tissue was highest in three tissue. It may be play an important role in carcinogenesis and progress of laryngeal carcinoma.

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内皮素-1在喉癌组织中的表达

目的:探讨内皮素-1在喉癌组织中的表达及临床意义。方法:采用免疫组织化学(SP)法检测内皮素-1在30例喉癌、20例喉癌良性病变和10例喉癌组织中的表达。应用SPSS12分析内皮素-1表达与临床分期的关系。0软件。结果。内皮素-1在三种组织中均呈阳性表达。喉癌与喉良性病变、喉癌与正常喉粘膜、喉良性病变与正常喉粘膜有显著性差异(P)结论:内皮素-1在喉癌组织中的阳性表达在3种组织中最高。它可能在喉癌的发生发展中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology

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