[Expression and clinical significance of matrix metalloproteinase-2 in laryngeal squamous cell carcinoma].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Pub Date : 2006-12-01

Xiaoqian Wang, Yanchun Shan, Jiqun Wang, Sijin Luo

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Abstract

Objective: To investigate the relationship between the expression of matrix metalloproteinase-2 (MMP-2) and clinical significance of laryngeal squamous cell carcinomas (LSCC).

Method: Expression of the MMP-2 was detected by immunohistochemical method in 63 cases of LSCC, 20 cases of adjacent safety margin (ASM) and 18 cases of vocal cord polyp (VCP).

Result: The positive percentage of active MMP-2 expression were 66.7%, 33. 3% and 15. 0%, in LSCC,VCP and ASM respectively. Significant differences ( P <0. 05) were observed among the three group; there was a significant differences in the expression of MMP-2 among the different pathologic degree I , II , III; no significant difference in the expression of MMP-2 between lymphoid metastasis and no lymphoid metastasis ( P >0. 05); Age and clinical stage did not change the expressions of the MMP-2 expression ( P <0. 05).

Conclusion: MMP-2 probably plays an important role in the carcinogenesis and progression of LSCC. But it may be an unnecessary factor in the metastases of LSCC.

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基质金属蛋白酶-2在喉癌组织中的表达及临床意义

目的:探讨基质金属蛋白酶-2 (MMP-2)表达与喉鳞癌(LSCC)临床意义的关系。方法:采用免疫组化方法检测63例LSCC、20例相邻安全缘(ASM)和18例声带息肉(VCP)组织中MMP-2的表达。结果:MMP-2阳性表达率为66.7%;3%和15%。在LSCC、VCP和ASM中分别为0%。差异有统计学意义(P < 0.05)。05);结论:MMP-2可能在LSCC的癌变和发展中起重要作用。但它可能是LSCC转移的一个不必要的因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology

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