[Expression of Survivin and its correlation with tumor angiogenesis in differentiated thyroid carcinomas].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Pub Date : 2006-11-01

Wenrong Dong, Xiaoming Li, Xiuying Lu, Bin Di, Jing Ma, Liping Cui

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Abstract

Objective: To identify the expression of Survivin and its relationship with tumor angiogenesis in differentiated thyroid carcinomas.

Method: The expression of Survivin, VEGF and MVD were detected by immuno-histochemical staining (SP methods) in 47 differentiated thyroid carcinomas, 10 thyroid adenoma and 10 normal thyroid tissues and their content were measured by pathological image analysis system.

Result: The expression of Survivin and VEGF in differentiated thyroid carcinomas was 46.8% and 61.7%, respectively. No expression of Survivin was detected in thyroid adenoma and normal thyroid tissues. The expression of Survivin was significantly correlated with the expression of VEGF and MVD in differentiated thyroid carcinomas. The expression of Survivin was significantly associated with clinical stages, tumor complete capsule and lymph node metastasis.

Conclusion: The up-regulation of Survivin expression and its close relationship with angiogenesis may play an important role in carcinogenesis and development of differentiated thyroid carcinomas.

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Survivin在分化型甲状腺癌中的表达及其与肿瘤血管生成的关系。

目的:探讨分化型甲状腺癌中Survivin的表达及其与肿瘤血管生成的关系。方法:采用免疫组化染色法(SP法)检测47例分化甲状腺癌、10例甲状腺腺瘤和10例正常甲状腺组织中Survivin、VEGF和MVD的表达，并采用病理图像分析系统检测其含量。结果:Survivin和VEGF在分化型甲状腺癌中的表达分别为46.8%和61.7%。Survivin在甲状腺腺瘤和正常甲状腺组织中未见表达。Survivin的表达与分化型甲状腺癌中VEGF、MVD的表达有显著相关性。Survivin的表达与临床分期、肿瘤完全包膜及淋巴结转移有显著相关性。结论:Survivin的表达上调及其与血管生成的密切关系可能在分化型甲状腺癌的发生发展中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology

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