[The effect of nuclear factor-kappaB protein expression in spiral ganglion cells of cochlea by overdosage sodium salicylate injection in guinea pigs].

Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology Pub Date : 2006-10-01

Hong Lü, Lilian Wu, Ying Zeng

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Abstract

Objective: To study the effect of sodium salicylate on the nuclear factor-kappaB (NF-kappaB) protein expression in spiral ganglion cells.

Method: Forty-eight healthy guinea pigs were randomly divided into four groups: group A: the control group (0.9% sodium chloride); group B: sodium salicylate [450 mg/(kg x d)] group; group C: sodium salicylate [450 mg/(kg x d)]+chlorpromazine [5 mg/(kg x d)] group; group D: sodium salicylate [450 mg/(kg x d)] +nimodipine [3 mg/(kg x d)] group. The protein expression level of NF-kappaB was examined by immunohistochemical method.

Result: The protein expression of NF-kappaB in spiral ganglion cells of group B was significantly higher than that of other groups.

Conclusion: Sodium salicylate can promote the protein expression of NF-kappaB in cochlear spiral ganglion cells. Nimodipine and chloropazine can weaken the protein expression of NF-kappaB, which is caused by sodium salicylate in cochlear spiral ganglion cells.

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[过量水杨酸钠注射对豚鼠耳蜗螺旋神经节细胞核因子- κ b蛋白表达的影响]。

目的:研究水杨酸钠对螺旋神经节细胞核因子κ b (nf - κ b)蛋白表达的影响。方法:48只健康豚鼠随机分为4组:A组:对照组(0.9%氯化钠);B组:水杨酸钠[450 mg/(kg × d)]组;C组:水杨酸钠[450 mg/(kg × d)]+氯丙嗪[5 mg/(kg × d)]组;D组:水杨酸钠[450 mg/(kg × D)] +尼莫地平[3 mg/(kg × D)]组。免疫组化法检测NF-kappaB蛋白表达水平。结果:B组螺旋神经节细胞NF-kappaB蛋白表达明显高于其他各组。结论:水杨酸钠可促进耳蜗螺旋神经节细胞NF-kappaB蛋白表达。尼莫地平和氯哌嗪可减弱水杨酸钠引起的耳蜗螺旋神经节细胞NF-kappaB蛋白表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology

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