Is there an optimal ribosome concentration for maximal protein production?

J L Snoep, H V Westerhoff, J M Rohwer, J H S Hofmeyr
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引用次数: 5

Abstract

A core model is presented for protein production in Escherichia coli to address the question whether there is an optimal ribosomal concentration for non-ribosome protein production. Analysing the steady-state solution of the model over a range of mRNA concentrations, indicates that such an optimum ribosomal content exists, and that the optimum shifts to higher ribosomal contents at higher specific growth rates.

是否有一个最佳的核糖体浓度,以最大限度地产生蛋白质?
提出了大肠杆菌蛋白生产的核心模型,以解决是否存在非核糖体蛋白生产的最佳核糖体浓度的问题。在mRNA浓度范围内分析模型的稳态溶液,表明存在这样一个最佳核糖体含量,并且在更高的特定生长速率下,最佳核糖体含量会向更高的核糖体含量转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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