{"title":"Severe desquamating disorder after liver transplant: toxic epidermal necrolysis or graft versus host disease?","authors":"John T Schulz, Robert L Sheridan","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The objective of this article is to present and discuss the clinical characteristics of TEN (Toxic Epidermal Necrolysis) and GVHD (Graft Versus Host Disease) following orthotopic liver transplantation.</p><p><strong>Methods: </strong>Recent experience with a patient who suffered a fatal desquamation syndrome within weeks of liver transplantation provides the basis for a discussion of differential diagnosis of these two conditions.</p><p><strong>Results: </strong>TEN and GVHD demonstrate similar clinical presentations as well as etiology (CD8+ lymphocyte attack on epithelial surfaces). This case demonstrates the difficulty in distinguishing between these two conditions in this particular patient.</p><p><strong>Conclusions: </strong>Advances in the understanding and treatment of one of these disease states may provide therapeutic insights into the other.</p>","PeriodicalId":87438,"journal":{"name":"Journal of burns and wounds","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2006-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1687152/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of burns and wounds","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The objective of this article is to present and discuss the clinical characteristics of TEN (Toxic Epidermal Necrolysis) and GVHD (Graft Versus Host Disease) following orthotopic liver transplantation.
Methods: Recent experience with a patient who suffered a fatal desquamation syndrome within weeks of liver transplantation provides the basis for a discussion of differential diagnosis of these two conditions.
Results: TEN and GVHD demonstrate similar clinical presentations as well as etiology (CD8+ lymphocyte attack on epithelial surfaces). This case demonstrates the difficulty in distinguishing between these two conditions in this particular patient.
Conclusions: Advances in the understanding and treatment of one of these disease states may provide therapeutic insights into the other.
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