Importance of improving tissue perfusion during treatment of hypertension.

Bernard Lévy
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引用次数: 4

Abstract

Experimental and clinical studies have established a link between end-organ damage in hypertensive patients and the severe impairment of tissue perfusion and microcirculation structure and function. Microvascular rarefaction is constantly observed in hypertension, and probably contributes to higher systemic resistance and lower tissue perfusion. Endothelial dysfunction leading to impaired arteriolar reactivity is also characteristic of the microvascular dysfunction in hypertensive patients. The effective lowering of blood pressure while maintaining optimal tissue perfusion is therefore one of the major goals of antihypertensive therapy, in order to improve the cardiovascular prognosis of hypertensive patients.

高血压治疗中改善组织灌注的重要性。
实验和临床研究已经证实了高血压患者终末器官损伤与组织灌注和微循环结构功能严重受损之间的联系。高血压患者经常观察到微血管稀疏,这可能导致更高的全身阻力和更低的组织灌注。内皮功能障碍导致小动脉反应性受损也是高血压患者微血管功能障碍的特征。因此,在保持最佳组织灌注的同时有效降低血压是降压治疗的主要目标之一,以改善高血压患者的心血管预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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