New aspects of cadmium as endocrine disruptor.

Masufumi Takiguchi, Shin'ichi Yoshihara
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Abstract

Cadmium (Cd) is an industrial and environmental pollutant that exerts adverse effects on a number of organs in humans and animals. Reproductive organs, such as the testis and placenta, are sensitive to the toxic effects of Cd. In animal experiments, high-dose exposure to Cd induced severe testicular interstitial hemorrhage with edema, and increased incidence of fetal death and placental necrosis. Low-dose exposure to Cd affects steroid synthesis in male and female reproductive organs. In 1998, the Ministry of Environment in Japan listed Cd in the strategy plan SPEED98 as one of the chemicals suspected of having possible endocrine disrupting activity. Recently, it has been shown that Cd has potent estrogen- and androgen-like activities in vivo and in vitro, by directly binding to estrogen and androgen receptors. However, the precise mechanisms underlying the effects of Cd as an endocrine disruptor remain to be elucidated. In this review, we will discuss evidence thus far presented concerning the effects of Cd on the endocrine system.

镉作为内分泌干扰物的新认识。
镉(Cd)是一种工业和环境污染物,对人类和动物的许多器官产生不利影响。生殖器官,如睾丸和胎盘,对Cd的毒性作用很敏感。在动物实验中,高剂量的Cd暴露会导致严重的睾丸间质出血伴水肿,并增加胎儿死亡和胎盘坏死的发生率。低剂量接触镉会影响男性和女性生殖器官的类固醇合成。1998年,日本环境省在战略计划SPEED98中将Cd列为可能具有内分泌干扰活性的化学品之一。近年来,研究表明,Cd通过直接与雌激素和雄激素受体结合,在体内和体外具有强效的雌激素和雄激素样活性。然而,Cd作为内分泌干扰物的作用的确切机制仍有待阐明。在这篇综述中,我们将讨论迄今为止有关镉对内分泌系统影响的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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