Cardiovascular roles of estrogen receptors: insights gained from knockout models.

Nuclear receptor signaling Pub Date : 2003-01-01 Epub Date: 2003-06-15 DOI:10.1621/nrs.01003
Michio Otsuki, Karin Dahlman-Wright, Jan-Ake Gustafsson
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引用次数: 7

Abstract

The effects of estrogen are mediated through two functionally distinct receptors, estrogen receptor alpha (ER- alpha ), and estrogen receptor beta (ER- beta ), both of which are expressed in the cardiovascular system. The etiology of cardiovascular disease is believed to result in part from the loss of endogenous estrogen, indicating that estrogen and its receptors may play important roles in the prevention of cardiovascular disease in women.

Abstract Image

雌激素受体的心血管作用:从敲除模型中获得的见解。
雌激素的作用是通过两种功能不同的受体介导的,雌激素受体α (ER- α)和雌激素受体β (ER- β),两者都在心血管系统中表达。心血管疾病的病因被认为部分是由于内源性雌激素的丧失,这表明雌激素及其受体可能在预防女性心血管疾病中发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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