Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Andrew Zannettino, Stan Gronthos, Tetsunori Seki, Silviu Itescu
{"title":"Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium.","authors":"Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Andrew Zannettino, Stan Gronthos, Tetsunori Seki, Silviu Itescu","doi":"10.1038/ncpcardio0404","DOIUrl":null,"url":null,"abstract":"<p><p>Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.</p>","PeriodicalId":51263,"journal":{"name":"Nature Clinical Practice. Cardiovascular Medicine","volume":"3 Suppl 1 ","pages":"S18-22"},"PeriodicalIF":0.0000,"publicationDate":"2006-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/ncpcardio0404","citationCount":"103","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Clinical Practice. Cardiovascular Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/ncpcardio0404","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 103
Abstract
Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery.
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