[Association study between NPY and YWHAH gene polymorphisms and schizophrenia].

Hong-Sheng Wang, Shi-Wei Duan, Qing-He Xing, Jing Du, Xing-Wang Li, Yi-Feng Xu, Zhi-Zhou Zhang, Yu-Jiong Wang, Guo-Yin Feng, Lin He
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Abstract

A case-control study was carried out on a sample of 583 cases vs. 372 controls in the Chinese Han population, investigating several published polymorphisms in the YWHAH and NPY genes, which reported to be associated with schizophrenia. The polymorphism -134 (GCCTGCA)2-4, in the YWHAH was not analyzed for the failure of amplification, and the polymorphism T1128C in the NPY is not existent in the samples. The analysis was then emphasized on the variants -485C > T(NPY) and G753A(YWHAH). However, no significant differences of allele frequencies (with P values of 0.696 and 0.743, OR values of 1.041 and 0.962 respectively) or genotype frequencies (with P value of 0.45 and 0.75, chi2 = 1.51 and 0.58 respectively) among the matched groups were found. No sex-dependent effect was found either. Also,the analysis of the relative risk between the genotypes of the two genes indicates that the two genes could not cooperate with each other to add the risk of disease (P > 0.05). The results suggest that the polymorphisms - 485C > T (NPY) and G753A (YWHAH) are unlikely to be linked with genetic susceptibility to schizophrenia in the Chinese Han population.

NPY和YWHAH基因多态性与精神分裂症的相关性研究
一项病例对照研究对中国汉族人群中583例病例和372例对照进行了研究,调查了几种已发表的与精神分裂症相关的YWHAH和NPY基因多态性。未分析YWHAH中-134 (GCCTGCA)2-4,多态性扩增失败,样品中不存在NPY中的T1128C多态性。然后着重分析变型-485C > T(NPY)和G753A(YWHAH)。配对组间等位基因频率(P值分别为0.696和0.743,OR值分别为1.041和0.962)和基因型频率(P值分别为0.45和0.75,chi2分别为1.51和0.58)差异不显著。也没有发现性别依赖效应。两种基因型的相对风险分析表明,两种基因不能相互合作增加患病风险(P > 0.05)。结果提示- 485C > T (NPY)和G753A (YWHAH)多态性不太可能与中国汉族人群精神分裂症的遗传易感性相关。
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