[Etiopathogenic hypothesis on carcinoma of the gallbladder: our study].

A G Rizzo, M Barbuscia, M Sanò, A Cancellieri, P Nicotina, G Stassi, G Lemma, F Lemma
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引用次数: 0

Abstract

The authors are interested in determining causes of gallbladder cancer (GBC). By this intention, they theorize a correlation between genetic modifications (which are responsible of malignant transformation of biliary epithelium) and some intestinal infections. From 1999 to 2004 they observed 15 GBC and all 15 gallbladder have been analyzed histologically and from microbiological aspect; by these means from 1999 till 2004 they have studied also 30 persons with colelithiasis. The authors noticed that bile of both groups contained, in three cases in the first and in 8 cases in the second, a germ named Escherichia Coli which normally lives in intestine, while in 10 operated gallbladders of the first group and 12 of the second there was a positive for k-ras. They are studying to confirm their theories.

胆囊癌的发病假说:我们的研究。
作者感兴趣的是确定胆囊癌(GBC)的原因。基于这一目的,他们推测基因修饰(胆上皮恶性转化的原因)与某些肠道感染之间存在相关性。从1999年到2004年,他们观察了15例GBC,并对所有15例胆囊进行了组织学和微生物学分析;通过这些方法,从1999年到2004年,他们还研究了30名结肠结石患者。作者注意到,两组的胆汁中,第一组有3例,第二组有8例,含有一种通常生活在肠道中的细菌,称为大肠杆菌,而第一组有10例,第二组有12例,k-ras呈阳性。他们正在研究以证实他们的理论。
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