Prevalence and risk factors of Helicobacter pylori infection in healthy schoolchildren.

Kamal E Bani-Hani, Nawaf J Shatnawi, Saleh El Qaderi, Yousef S Khader, Bayan K Bani-Hani
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引用次数: 32

Abstract

Objective: Data regarding the prevalence of Helicobacter pylori infection and its potential risk factors among schoolchildren from the Middle East is scarce.

Methods: An enzyme-linked immunosorbent assay was used to investigate H. pylori status in four groups of children: The first and second groups, 50 children each (25 boys, 25 girls) included children from high socioeconomic class (group 1 = 6 years old; group 2 = 9 years old). The third and fourth groups were sex- and age-matched, but from low socioeconomic class. To evaluate the association between the seroprevalence of H. pylori and selected risk factors, odds ratios (crude and adjusted) were calculated using multiple regression analysis.

Results: Overall seroprevalence rate was 55.5%. Seropositivity was 42%, 52%, 60%, and 68% for groups 1, 2, 3, and 4, respectively. Age and sex were not significantly associated with H. pylori seropositivity. In the final logistic regression model, which was adjusted for age and sex, the following risk factors were found to be significantly associated with seropositivity: living in rural areas (P = 0.015), poor sanitation (P < 0.001), overcrowding (P = 0.014), low maternal educational level (P = 0.010) and low socioeconomic status (P = 0.011).

Conclusions: The prevalence of H. pylori infection in Jordanian schoolchildren is high, suggesting that most acquisition occurs before the age of 6 years. The seroprevalence for H. pylori increases with social deprivation.

健康学童幽门螺杆菌感染流行及危险因素分析。
目的:关于中东学童幽门螺杆菌感染流行及其潜在危险因素的资料很少。方法:采用酶联免疫吸附法调查四组儿童幽门螺杆菌感染情况:第一组和第二组各50例(男25例,女25例),包括社会经济地位高的儿童(组1 = 6岁;第二组= 9岁)。第三组和第四组性别和年龄匹配,但来自低社会经济阶层。为了评估幽门螺杆菌血清患病率与选定危险因素之间的关系,采用多元回归分析计算比值比(粗比值比和校正比值比)。结果:总血清阳性率为55.5%。1、2、3、4组血清阳性率分别为42%、52%、60%、68%。年龄和性别与幽门螺杆菌血清阳性无显著相关。在最后的logistic回归模型中,调整了年龄和性别,发现以下危险因素与血清阳性显著相关:生活在农村(P = 0.015)、卫生条件差(P < 0.001)、过度拥挤(P = 0.014)、母亲教育水平低(P = 0.010)和社会经济地位低(P = 0.011)。结论:幽门螺杆菌感染在约旦学龄儿童中的患病率很高,这表明大多数感染发生在6岁之前。幽门螺杆菌的血清患病率随着社会剥夺而增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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