Invasive aspergillosis in association with criminal arsenic poisoning

Muriel Parent , Philippe Hantson , Vincent Haufroid , Jean-François Heilier , Paul Mahieu , Frédéric Bonbled
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引用次数: 5

Abstract

A 26-year-old man suffered acute arsenic poisoning after a poisoning attempt. He developed multiple organ failure including encephalopathy, bleeding disorders, pancreatitis, renal and hepatocellular impairment. Generalized erythroderma also developed within one week after admission. The developed acute respiratory distress syndrome and Aspergillus fumigatus was isolated from the endotracheal aspirate. Despite intensive care support, antidote administration and various epuration techniques, the patient died on day 26 from subarachnoid bleeding. An autopsy was obtained and the concentration of arsenic was determined in different tissues. Multiple abscesses due to Aspergillus fumigatus were seen in the lungs, myocardium and kidneys. This uncommon complication in a previously immunocompetent patient could be related to impaired immunity directly caused by arsenic poisoning.

与刑事砷中毒有关的侵袭性曲霉病
一名26岁的男子在尝试投毒后急性砷中毒。他出现了多器官衰竭,包括脑病、出血性疾病、胰腺炎、肾脏和肝细胞损伤。全身性红皮病也在入院后一周内发生。急性呼吸窘迫综合征及烟曲霉从气管内吸出。尽管有重症监护支持、解毒剂治疗和各种清洗技术,患者仍于第26天死于蛛网膜下腔出血。进行了尸检,并确定了不同组织中的砷浓度。肺部、心肌和肾脏可见烟曲霉引起的多发脓肿。这种罕见的并发症出现在以前免疫功能正常的病人身上,可能与砷中毒直接引起的免疫功能受损有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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