The fitness costs and benefits of trisomy of each Candida albicans chromosome.

IF 3.3 3区 生物学
Genetics Pub Date : 2021-06-24 DOI:10.1093/genetics/iyab056
Feng Yang, Robert T Todd, Anna Selmecki, Yuan-Ying Jiang, Yong-Bing Cao, Judith Berman
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引用次数: 0

Abstract

Candida albicans is a prevalent human fungal pathogen. Rapid genomic change, due to aneuploidy, is a common mechanism that facilitates survival from multiple types of stresses including the few classes of available antifungal drugs. The stress survival of aneuploids occurs despite the fitness costs attributed to most aneuploids growing under idealized lab conditions. Systematic study of the aneuploid state in C. albicans has been hindered by the lack of a comprehensive collection of aneuploid strains. Here, we describe a collection of diploid C. albicans aneuploid strains, each carrying one extra copy of each chromosome, all from the same genetic background. We tested the fitness of this collection under several physiological conditions including shifts in pH, low glucose, oxidative stress, temperature, high osmolarity, membrane stress, and cell wall stress. We found that most aneuploids, under most conditions, were less fit than their euploid parent, yet there were specific conditions under which specific aneuploid isolates provided a fitness benefit relative to the euploid parent strain. Importantly, this fitness benefit was attributable to the change in the copy number of specific chromosomes. Thus, C. albicans can tolerate aneuploidy of each chromosome and some aneuploids confer improved growth under conditions that the yeast encounters in its host niches.

Abstract Image

Abstract Image

每条白色念珠菌染色体三体的适应度成本和收益。
白色念珠菌是一种常见的人类真菌病原体。由于非整倍体,快速的基因组变化是一种常见的机制,有助于从多种类型的压力中生存,包括几种可用的抗真菌药物。尽管大多数非整倍体在理想的实验室条件下生长需要付出适应度成本,但非整倍体的应激存活仍然发生。白色念珠菌非整倍体状态的系统研究一直受到缺乏全面收集非整倍体菌株的阻碍。在这里,我们描述了一个二倍体白色念珠菌非整倍体菌株的集合,每个携带一个额外的染色体拷贝,所有来自相同的遗传背景。我们在几种生理条件下测试了该集合的适应性,包括pH值变化、低糖、氧化应激、温度、高渗透压、膜应激和细胞壁应激。我们发现,在大多数条件下,大多数非整倍体比它们的整倍体亲本更不适合,但在特定条件下,特定的非整倍体分离物相对于整倍体亲本菌株提供了适应性优势。重要的是,这种适应性益处可归因于特定染色体拷贝数的变化。因此,白色念珠菌可以忍受每条染色体的非整倍体,一些非整倍体在酵母在其宿主生态位中遇到的条件下可以改善生长。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Genetics
Genetics 生物-遗传学
CiteScore
6.20
自引率
6.10%
发文量
177
期刊介绍: GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.
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