Effect of chelation therapy on arrhythmogenic and basal ECG parameters of lead exposed workers.

IF 0.9 4区医学 Q4 ENVIRONMENTAL SCIENCES

Archives of Environmental & Occupational Health Pub Date : 2022-01-01 Epub Date: 2021-04-10 DOI:10.1080/19338244.2021.1910116

Mustafa Karanfil, Meşide Gündüzöz, Murat Karakurt, Emre Aruğaslan, Mustafa Bilal Özbay, Sefa Ünal, Kürşat Akbuğa, Ahmet Akdi, Mehmet Akif Erdöl, Ahmet Göktuğ Ertem, Çağrı Yayla, Özcan Özeke

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引用次数: 0

Abstract

Lead exposure has etiological role on cardiovascular system diseases as hypertension, atherosclerosis, stroke, and arrhythmic events. In this study, we aimed to compare the basal and arrhythmogenic ECG parameters of lead exposed workers before and after chelation therapy and to evaluate the effect of acute change of blood lead levels on ECG. Fourty consecutive occupationally lead exposed workers were enrolled, demographic, blood, echocardiographic, and electrocardiographic data's were analyzed before and after chelation therapy. Pmax, P min, P Wave Dispersion, and QT Dispersion values which are arrhythmia predictors were significantly lower after chelation therapy compared to values before chelation therapy. Lead exposed workers are under the risk of ventricular and atrial arrythmias and chelation treatment has a positive effect on these parameters.

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螯合治疗对铅暴露工人致心律失常及基础心电图参数的影响。

铅暴露对高血压、动脉粥样硬化、中风和心律失常等心血管系统疾病具有病因学作用。在本研究中，我们旨在比较铅暴露工人在螯合治疗前后的基础心电图和致心律失常参数，并评估血铅水平的急性变化对心电图的影响。选取40名连续职业性铅暴露工人，分析其螯合治疗前后的人口统计、血液、超声心动图和心电图数据。与螯合治疗前相比，螯合治疗后作为心律失常预测指标的Pmax、pmin、P波离散度和QT离散度值显著降低。铅暴露工人有室性心律失常和心房性心律失常的危险，螯合治疗对这些参数有积极影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Environmental & Occupational Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

3.70

自引率

0.00%

发文量

审稿时长

>36 weeks

期刊介绍： Archives of Environmental & Occupational Health , originally founded in 1919 as the Journal of Industrial Hygiene, and perhaps most well-known as the Archives of Environmental Health, reports, integrates, and consolidates the latest research, both nationally and internationally, from fields germane to environmental health, including epidemiology, toxicology, exposure assessment, modeling and biostatistics, risk science and biochemistry. Publishing new research based on the most rigorous methods and discussion to put this work in perspective for public health, public policy, and sustainability, the Archives addresses such topics of current concern as health significance of chemical exposure, toxic waste, new and old energy technologies, industrial processes, and the environmental causation of disease such as neurotoxicity, birth defects, cancer, and chronic degenerative diseases. For more than 90 years, this noted journal has provided objective documentation of the effects of environmental agents on human and, in some cases, animal populations and information of practical importance on which decisions are based.