Structures and functions of multi-tRNA synthetase complexes.

Q3 Biochemistry, Genetics and Molecular Biology
Enzymes Pub Date : 2020-01-01 Epub Date: 2020-09-08 DOI:10.1016/bs.enz.2020.06.008
Myung Hee Kim, Sunghoon Kim
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引用次数: 6

Abstract

Human body is a finely-tuned machine that requires homeostatic balance based on systemically controlled biological processes involving DNA replication, transcription, translation, and energy metabolism. Ubiquitously expressed aminoacyl-tRNA synthetases have been investigated for many decades, and they act as cross-over mediators of important biological processes. In particular, a cytoplasmic multi-tRNA synthetase complex (MSC) appears to be a central machinery controlling the complexity of biological systems. The structural integrity of MSC determined by the associated components is correlated with increasing biological complexity that links to system development in higher organisms. Although the role of the MSCs is still unclear, this chapter describes the current knowledge on MSC components that are associated with and regulate functions beyond their catalytic activities with focus on human MSC.

多trna合成酶复合物的结构和功能。
人体是一台精密调谐的机器,需要基于系统控制的生物过程的稳态平衡,包括DNA复制、转录、翻译和能量代谢。普遍表达的氨基酰基trna合成酶已经被研究了几十年,它们在重要的生物过程中起着交叉介质的作用。特别是,细胞质多trna合成酶复合物(MSC)似乎是控制生物系统复杂性的中心机制。由相关成分决定的间充质干细胞的结构完整性与与高等生物系统发育相关的生物复杂性的增加有关。尽管间充质干细胞的作用尚不清楚,但本章描述了目前关于间充质干细胞成分的知识,这些成分与人类间充质干细胞的催化活性之外的功能相关并进行调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Enzymes
Enzymes Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
4.30
自引率
0.00%
发文量
10
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