Antimicrobial Susceptibility of Corynebacterium bovis Isolates from Immunodeficient Rodents.

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Comparative medicine Pub Date : 2021-06-01 Epub Date: 2021-04-08 DOI:10.30802/AALAS-CM-20-000107
Anna C Fagre, Uma Pugazhenthi, Christopher Cheleuitte-Nieves, Marcus J Crim, Kenneth S Henderson, Derek L Fong, Jori K Leszczynski, Michael J Schurr, Joshua B Daniels, Christopher A Manuel
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引用次数: 0

Abstract

Corynebacterium bovis, the causative agent of hyperkeratotic dermatitis in immunodeficient mice, is a significant problem in preclinical oncology research. Infection results in lifelong skin colonization and a decrease in successful engraftment of patient-derived xenograft tumor models. The use of antimicrobial agents for C. bovis is controversial in light of reports of poor efficacy and the possibility of selection for resistant strains. The purpose of this study was to describe the antimicrobial susceptibilities of C. bovis isolates obtained exclusively from immunodeficient rodents in order to aid in antimicrobial dose determination. Between 1995 and 2018, 15 isolates were collected from 11 research institutions across the United States. Antimicrobial susceptibility testing was performed for 24 antimicrobials commonly used against gram-positive bacteria. Our results provide an updated understanding of the susceptibility profiles of rodent C. bovis isolates, indicating little variability between geographically and temporally distant isolates. These results will facilitate appropriate antimicrobial use to prevent and treat C. bovis infections in immunodeficient rodents.

从免疫缺陷啮齿动物中分离出的牛棒状杆菌对抗菌素的敏感性
牛海绵状杆菌是免疫缺陷小鼠过度角化性皮炎的致病菌,也是临床前肿瘤学研究中的一个重要问题。感染会导致皮肤终生定植,并降低患者异种移植肿瘤模型的成功接种率。由于有报告称牛海绵状芽孢杆菌抗菌剂的疗效不佳,而且有可能导致耐药菌株的产生,因此使用抗菌剂治疗牛海绵状芽孢杆菌还存在争议。本研究的目的是描述完全从免疫缺陷啮齿动物中分离出的牛肝菌的抗菌药敏感性,以帮助确定抗菌药剂量。1995 年至 2018 年间,研究人员从全美 11 家研究机构收集了 15 个分离株。对 24 种常用的革兰氏阳性菌抗菌药进行了抗菌药敏感性测试。我们的研究结果提供了对啮齿动物牛海绵状芽孢杆菌分离物药敏谱的最新了解,表明地理上和时间上遥远的分离物之间几乎没有差异。这些结果将有助于适当使用抗菌药物预防和治疗免疫缺陷啮齿动物的牛海绵状芽孢杆菌感染。
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来源期刊
Comparative medicine
Comparative medicine 医学-动物学
CiteScore
1.90
自引率
0.00%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.
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