Influence of puberty on retinal microcirculation in children with type 1 diabetes without retinopathy using optical coherence tomography angiography.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2021-03-01 DOI:10.1177/14791641211004427

Marta Wysocka-Mincewicz, Joanna Gołębiewska, Marta Baszyńska-Wilk, Andrzej Olechowski, Aleksandra Byczyńska, Mieczysław Szalecki

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引用次数: 2

Abstract

Background: This study aimed to assess the influence of pubertal status on the results of optical coherence tomography angiography (OCTA) in children with type 1 diabetes (T1D).

Methods: We enrolled 167 consecutive children with T1D. Retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) vessel density data underwent analysis. We divided the study population into three subgroups depending on the pubertal status.

Results: Analysis of the prepubertal and pubertal subgroups revealed statistically significant differences in foveal thickness (FT) (p < 0.05) and foveal SCP (p < 0.02). Analyzing subgroups of the prepubertal and postpubertal children, we observed statistically significant differences in FT (p < 0.03), whole SCP (p < 0.02), and foveal SCP (p < 0.02). Comparison of the pubertal and postpubertal subjects revealed differences in parafoveal DCP (p < 0.003). In the groups matched depending on diabetes duration, we observed differences between prepubertal, pubertal, and postpubertal children in FT, PFT, and parafoveal SCP and DCP.

Conclusion: Our data suggest that in a cohort of pubertal children with a short duration of diabetes, alterations in retinal vessel density occur early and progress during puberty.

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青春期对无视网膜病变1型糖尿病儿童视网膜微循环的影响

背景:本研究旨在评估青春期状态对1型糖尿病(T1D)儿童光学相干断层扫描血管造影(OCTA)结果的影响。方法:我们连续招募167例T1D患儿。分析视网膜浅毛细血管丛(SCP)和深毛细血管丛(DCP)血管密度数据。我们根据青春期状态将研究人群分为三个亚组。结果:对青春期前和青春期亚组的分析显示，在中央凹厚度(FT)上有统计学意义的差异(p)。结论:我们的数据表明，在一组患有短时间糖尿病的青春期儿童中，视网膜血管密度的改变发生得早，并在青春期进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)