Biochemical and molecular responses of the Mediterranean mussel (Mytilus galloprovincialis) to short-term exposure to three commonly prescribed drugs

IF 3 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Marine environmental research Pub Date : 2021-06-01 DOI:10.1016/j.marenvres.2021.105309

Katia Pes , Annika Friese , Cymon J. Cox , Vincent Laizé , Ignacio Fernández

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引用次数: 7

Abstract

Pharmaceuticals represent a group of emerging contaminants. The short-term effect (3 and 7 days) of warfarin (1 and 10 mg L⁻¹), dexamethasone (0.392 and 3.92 mg L⁻¹) and imidazole (0.013 and 0.13 mg L⁻¹) exposure was evaluated on mussels (Mytilus galloprovincialis). Total antioxidant status, glutathione reductase, glutathione peroxidase (GPx) and superoxide dismutase enzyme activities, and the expression of genes involved in the xenobiotic response (ATP binding cassette subfamily B member 1 (abcb1) and several nuclear receptor family J (nr1j) isoforms), were evaluated. All nr1j isoforms are suggested to be the xenobiotic receptor orthologs of the NR1I family. All drugs increased GPx activity and altered the expression of particular nr1j isoforms. Dexamethasone exposure also decreased abcb1 expression. These findings raised some concerns regarding the release of these pharmaceuticals into the aquatic environment. Thus, further studies might be needed to perform an accurate environmental risk assessment of these 3 poorly studied drugs.

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地中海贻贝(Mytilus galloprovincialis)短期暴露于三种常用处方药后的生化和分子反应

药品代表了一组新出现的污染物。研究了华法林(1和10 mg L−1)、地塞米松(0.392和3.92 mg L−1)和咪唑(0.013和0.13 mg L−1)对贻贝(Mytilus galloprovincialis)的短期效应(3和7天)。评估了总抗氧化状态、谷胱甘肽还原酶、谷胱甘肽过氧化物酶(GPx)和超氧化物歧化酶活性，以及参与外源反应的基因(ATP结合盒B亚家族成员1 (abcb1)和几种核受体家族J (nr1j)亚型)的表达。所有nr1j亚型都被认为是NR1I家族的异种受体同源物。所有药物均增加GPx活性并改变特定nr1j亚型的表达。地塞米松暴露也降低了abcb1的表达。这些发现引起了人们对这些药物释放到水生环境中的担忧。因此，可能需要进一步的研究来对这3种研究不足的药物进行准确的环境风险评估。

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来源期刊

Marine environmental research 环境科学-毒理学

CiteScore

5.90

自引率

3.00%

发文量

217

审稿时长

46 days

期刊介绍： Marine Environmental Research publishes original research papers on chemical, physical, and biological interactions in the oceans and coastal waters. The journal serves as a forum for new information on biology, chemistry, and toxicology and syntheses that advance understanding of marine environmental processes. Submission of multidisciplinary studies is encouraged. Studies that utilize experimental approaches to clarify the roles of anthropogenic and natural causes of changes in marine ecosystems are especially welcome, as are those studies that represent new developments of a theoretical or conceptual aspect of marine science. All papers published in this journal are reviewed by qualified peers prior to acceptance and publication. Examples of topics considered to be appropriate for the journal include, but are not limited to, the following: – The extent, persistence, and consequences of change and the recovery from such change in natural marine systems – The biochemical, physiological, and ecological consequences of contaminants to marine organisms and ecosystems – The biogeochemistry of naturally occurring and anthropogenic substances – Models that describe and predict the above processes – Monitoring studies, to the extent that their results provide new information on functional processes – Methodological papers describing improved quantitative techniques for the marine sciences.