[Early onset of methotrexate-associated lymphoproliferative disorder mimicking Hodgkin's lymphoma].

4区医学 Q3 Medicine

Hautarzt Pub Date : 2022-01-01 Epub Date: 2021-04-01 DOI:10.1007/s00105-021-04804-6

Maria Rosa Burg, Stefan W Schneider

引用次数: 1

Abstract

Long-term methotrexate (MTX) treatment is known to cause MTX-associated lymphoproliferative disorder (MTX-LPD). A 58-year-old woman with psoriasis vulgaris and pityriasis rubra pilaris was treated with a combination of MTX and ustekinumab for 4 months when she developed generalized lymphadenopathy. The initial histopathological analysis indicated Hodgkin's lymphoma; however, assessing the patient's clinical history revealed the diagnosis of MTX-LPD. To our knowledge, this is the first case of a MTX-LPD after only 4 months of treatment.

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[早期发病的甲氨蝶呤相关淋巴细胞增生性疾病，模拟霍奇金淋巴瘤]。

已知长期甲氨蝶呤(MTX)治疗可导致MTX相关淋巴细胞增生性疾病(MTX- lpd)。一名患有寻常型银屑病和毛疹性糠疹的58岁女性在出现全身性淋巴结病时，接受MTX和ustekinumab联合治疗4个月。最初的组织病理学分析为霍奇金淋巴瘤;然而，评估患者的临床病史显示诊断为MTX-LPD。据我们所知，这是第一例MTX-LPD治疗后仅4个月。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hautarzt 医学-皮肤病学

CiteScore

1.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Der Hautarzt is an internationally recognized journal informing all dermatologists working in practical or clinical environments about important developments in the field of dermatology including allergology, venereology and related areas. Comprehensive reviews on a specific topical issue focus on providing evidenced based information on diagnostics and therapy. Freely submitted original papers allow the presentation of important clinical studies and serve the scientific exchange. Case reports feature interesting cases and aim at optimizing diagnostic and therapeutic strategies. Review articles under the rubric "Continuing Medical Education" present verified results of scientific research and their integration into daily practice.