A toolkit for the application of placental-fetal molecular biomarkers in epidemiologic studies of the fetal origins of chronic disease.

3区医学

Current Epidemiology Reports Pub Date : 2021-03-01 Epub Date: 2020-12-28 DOI:10.1007/s40471-020-00258-x

Jennifer J Adibi, Alexander J Layden, Qing Yin, Xiaoshuang Xun, Shyamal Peddada, Rahel L Birru

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引用次数: 5

Abstract

Purpose of review: In this review, we provide essential background knowledge and an analytical framework for the application of placental-fetal molecular biomarkers in fetal origins chronic disease epidemiology. The widely available and highly quantitative placental hormone human chorionic gonadotropin (hCG) is used as an example. hCG is currently used for diagnosing fetal genetic disorders; yet it can and should be expanded to understanding the fetal origins of chronic diseases. We provide justification and methods to do this.

Recent findings: Ten papers published in the last 5 years were identified with supportive findings relevant to the application of biomarkers of hCG in epidemiologic studies on the developmental origins of health and disease (DOHaD).

Summary: There is increasing and consistent evidence that placental-fetal biomarkers may be highly informative in observational studies, as exemplified by hCG, with the correct approaches for measurement and data analysis.

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一个应用胎盘-胎儿分子生物标志物在慢性疾病胎儿起源的流行病学研究中的工具包。

综述目的:本文综述了胎盘-胎儿分子生物标志物在胎儿源性慢性病流行病学中的应用的基本背景知识和分析框架。本文以广泛使用且定量高的胎盘激素人绒毛膜促性腺激素(hCG)为例。hCG目前用于诊断胎儿遗传疾病;然而，它可以而且应该扩展到了解慢性疾病的胎儿起源。我们提供这样做的理由和方法。最近的发现:在过去5年发表的10篇论文中，我们发现了与hCG生物标志物在健康和疾病发展起源(DOHaD)的流行病学研究中的应用相关的支持性发现。总结:越来越多和一致的证据表明，在观察性研究中，胎盘-胎儿生物标志物可能具有很高的信息量，如hCG，采用正确的测量和数据分析方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Epidemiology Reports OTORHINOLARYNGOLOGY-

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审稿时长

3 months