Sarka Kankova, Marie Bicikova, Ludmila Macova, Jana Hlavacova, Katerina Sykorova, Dobroslava Jandova, Jaroslav Flegr
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引用次数: 2
Abstract
Numerous recent studies show that vitamin D deficiency potentiates various chronic physical and psychiatric disorders and diseases. It has been shown that a similar range of disorders is also associated with latent infection with Toxoplasma gondii (Nicolle et Manceaux, 1908). For instance, among cancer, diabetes and schizophrenia patients, we find a higher prevalence of both toxoplasmosis and vitamin D deficiency. Theoretically, therefore, vitamin D deficiency could be the missing link between toxoplasmosis and these disorders. We tested this hypothesis by searching for decreased vitamin D levels in the serum of subjects infected with T. gondii (furthermore called Toxoplasma-infected subjects) in two cross-sectional and one case-control study. Results of the first cross-sectional study (N = 72) suggest that Toxoplasma-infected neurasthenic patients have non-significantly lower levels of calcidiol than Toxoplasma-free patients (study A: P = 0.26 in women, P = 0.68 in men). However, two other studies (study B: N = 400; study C: N = 191) showed a non-significantly higher concentration of vitamin D in Toxoplasma-infected subjects than in Toxoplasma-free subjects both in men (study B: P = 0.70, study C: P = 0.55) and in women (study B: P = 0.64, study C: P = 0.12). Taken together, our preliminary results thus do not support the hypothesis that toxoplasmosis could be associated with vitamin D decrease.
最近的许多研究表明,维生素D缺乏会加剧各种慢性身体和精神疾病。研究表明,一系列类似的疾病也与弓形虫潜伏感染有关(Nicolle et Manceaux, 1908)。例如,在癌症、糖尿病和精神分裂症患者中,我们发现弓形虫病和维生素D缺乏症的患病率更高。因此,从理论上讲,维生素D缺乏可能是弓形虫病和这些疾病之间缺失的一环。我们通过在两项横断面研究和一项病例对照研究中寻找弓形虫感染受试者(也称为弓形虫感染受试者)血清中维生素D水平下降的情况来验证这一假设。第一个横断面研究的结果(N = 72)表明,感染弓形虫的神经衰弱患者的钙二醇水平不显著低于未感染弓形虫的患者(研究A:女性P = 0.26,男性P = 0.68)。然而,另外两项研究(研究B: N = 400;研究C: N = 191)显示,在男性(研究B: P = 0.70,研究C: P = 0.55)和女性(研究B: P = 0.64,研究C: P = 0.12)中,弓形虫感染受试者的维生素D浓度均未显著高于未感染弓形虫的受试者。综上所述,我们的初步结果因此不支持弓形虫病可能与维生素D减少有关的假设。
期刊介绍:
FOLIA PARASITOLOGICA, issued in online versions, is an international journal that covers the whole field of general, systematic, ecological and experimental parasitology. It publishes original research papers, research notes and review articles. Contributions from all branches of animal parasitology, such as morphology, taxonomy, biology, biochemistry, physiology, immunology, molecular biology and evolution of parasites, and host-parasite relationships, are eligible. Novelty and importance in the international (not local or regional) context are required. New geographical records of parasites, records of new hosts, regional parasite and/or host surveys (if they constitute the principal substance of manuscript), local/regional prevalence surveys of diseases, local/regional studies on epidemiology of well known diseases and of parasite impact on human/animal health, case reports, routine clinical studies and testing of established diagnostic or treatment procedures, will not be considered. One species description will also not be considered unless they include more general information, such as new diagnostic characters, host-parasite associations, phylogenetic implications, etc. Manuscripts found suitable on submission will be reviewed by at least two reviewers.