Polymers in topical delivery of anti-psoriatic medications and other topical agents in overcoming the barriers of conventional treatment strategies.

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Progress in Biomaterials Pub Date : 2021-03-01 Epub Date: 2021-03-18 DOI:10.1007/s40204-021-00154-7
Krishna Yadav, Akanksha Soni, Deependra Singh, Manju Rawat Singh
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引用次数: 13

Abstract

In recent decades, topical treatments to dermal disorders have shown ineffectiveness in delivering the medication at a particular location without a suitable drug carrier. Psoriasis treatment is hindered because of the ineffective delivery and efficacy of conventional pharmaceutical treatment. In conventional medication formulation approach, it is difficult to breach the transdermal layer of a skin membrane for topical drugs, i.e. cyclosporine, methotrexate. This problem is further complicated by extreme disease-associated conditions such as hyperkeratosis and irritation. Intending to assure better drug delivery carriers, this review emphasizes the therapeutic efficacy of polymers and their potential to deliver the drug into the deeper layer of the skin membrane. The polymers are essential in structural and physiochemical perspectives as it works as a carrier for the medication. A vast variety of delivery carriers is available nowadays but their applicability in such dermal cases like psoriasis is still lacking due to less knowledge on an appropriate polymer. The current investigation of suitable polymer would assist in brushing our expertise to optimize the advantages of a wide spectrum of polymers to fulfill the topical targeting of psoriasis.

聚合物在局部递送抗银屑病药物和其他局部药物克服常规治疗策略的障碍。
近几十年来,皮肤疾病的局部治疗在没有合适的药物载体的情况下,在特定位置递送药物无效。银屑病的治疗受到阻碍,因为传统药物治疗的无效传递和疗效。在传统的药物配方方法中,外用药物如环孢素、甲氨蝶呤很难突破皮肤膜的透皮层。极端疾病相关的情况,如角化过度和刺激,使这一问题进一步复杂化。为了确保更好的药物传递载体,本文着重介绍了聚合物的治疗效果及其将药物传递到皮肤膜深层的潜力。聚合物在结构和物理化学方面是必不可少的,因为它是药物的载体。现在有各种各样的递送载体,但由于对合适的聚合物的了解较少,它们在牛皮癣等皮肤病例中的适用性仍然缺乏。目前对合适聚合物的研究将有助于丰富我们的专业知识,以优化广谱聚合物的优势,以实现银屑病的局部靶向治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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