[Role of genetic factors in pneumonia and COVID-19].

Q4 Medicine
PNEUMOLOGE Pub Date : 2021-01-01 Epub Date: 2021-03-05 DOI:10.1007/s10405-021-00385-2
Wilhelm Bertrams, Anna Lena Jung, Michael Maxheim, Bernd Schmeck
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引用次数: 0

Abstract

Pneumonia causes the highest mortality of all infectious diseases worldwide. The most common pathogens are bacteria but there are also epidemic or pandemic lung infections caused by influenza or coronaviruses, such as the current pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to the occurrence of antibiotic resistance and immune pathologies, such as in sepsis, important challenges lie in considering the susceptibility of individual patients. Here, age, medication and comorbidities are considered; however, there is also clear evidence of genetic influences on the individual risk of developing pneumonia or developing a severe course of the disease. This article discusses the genetic influences on pneumonia and the clinical significance.

Abstract Image

[遗传因素在肺炎和COVID-19中的作用]。
肺炎是全世界所有传染病中死亡率最高的疾病。最常见的病原体是细菌,但也有由流感或冠状病毒引起的流行性或大流行性肺部感染,例如目前由严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)引起的大流行。除了抗生素耐药性和免疫病理的发生,如败血症,重要的挑战在于考虑个体患者的易感性。在这里,年龄、药物和合并症被考虑在内;然而,也有明确的证据表明,遗传对患肺炎或发展成严重病程的个人风险有影响。本文就遗传因素对肺炎的影响及临床意义进行探讨。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
PNEUMOLOGE
PNEUMOLOGE RESPIRATORY SYSTEM-
CiteScore
0.30
自引率
0.00%
发文量
24
期刊介绍: Zielsetzung der Zeitschrift Der Pneumologe bietet aktuelle Fortbildung für alle pneumologisch tätigen Ärztinnen und Ärzte in Praxis und Klinik. Inhaltlich werden alle Bereiche der Pneumologie praxisnah abgedeckt. Im Vordergrund stehen Prävention, diagnostische Vorgehensweisen und Komplikationsmanagement sowie moderne Therapiestrategien. Umfassende Übersichtsarbeiten zu einem aktuellen Schwerpunktthema sind das Kernstück jeder Ausgabe. Im Mittelpunkt steht gesichertes Wissen zu Diagnostik und Therapie mit hoher Relevanz für die tägliche Arbeit. Beiträge der Rubrik ''CME Zertifizierte Fortbildung'' bieten gesicherte Ergebnisse wissenschaftlicher Forschung und machen ärztliche Erfahrung für die tägliche Praxis nutzbar. Nach Lektüre der Beiträge können die Lesenden ihr erworbenes Wissen überprüfen und online CME-Punkte erhalten. Die Rubrik orientiert sich an der Weiterbildungsordnung des Fachgebiets. Aims & Scope Der Pneumologe offers up-to-date information for all pneumologists working in practical and clinical environments and scientists who are particularly interested in issues of pneumology. The focus is on current developments regarding prevention, diagnostic approaches, management of complications and current therapy strategies. Comprehensive reviews on a specific topical issue provide evidenced based information on diagnostics and therapy. Review articles under the rubric ''Continuing Medical Education'' present verified results of scientific research and their integration into daily practice. Indexed in Scopus. Review All articles of Der Pneumologe are reviewed.
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