Parathyroid hormone.

2区医学 Q1 Chemistry

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-07-20 DOI:10.1016/bs.acc.2020.06.005

Edward Ki Yun Leung

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引用次数: 5

Abstract

Parathyroid hormone is an essential regulator of extracellular calcium and phosphate. PTH enhances calcium reabsorption while inhibiting phosphate reabsorption in the kidneys, increases the synthesis of 1,25-dihydroxyvitamin D, which then increases gastrointestinal absorption of calcium, and increases bone resorption to increase calcium and phosphate. Parathyroid disease can be an isolated endocrine disorder or part of a complex syndrome. Genetic mutations can account for diseases of parathyroid gland formulation, dysregulation of parathyroid hormone synthesis or secretion, and destruction of the parathyroid glands. Over the years, a number of different options are available for the treatment of different types of parathyroid disease. Therapeutic options include surgical removal of hypersecreting parathyroid tissue, administration of parathyroid hormone, vitamin D, activated vitamin D, calcium, phosphate binders, calcium-sensing receptor, and vitamin D receptor activators to name a few. The accurate assessment of parathyroid hormone also provides essential biochemical information to properly diagnose parathyroid disease. Currently available immunoassays may overestimate or underestimate bioactive parathyroid hormone because of interferences from truncated parathyroid hormone fragments, phosphorylation of parathyroid hormone, and oxidation of amino acids of parathyroid hormone.

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甲状旁腺激素。

甲状旁腺激素是细胞外钙和磷酸盐的重要调节因子。甲状旁腺激素增强钙的重吸收，同时抑制磷酸盐在肾脏中的重吸收，增加1,25-二羟基维生素D的合成，从而增加钙的胃肠道吸收，并增加骨吸收以增加钙和磷酸盐。甲状旁腺疾病可以是一种孤立的内分泌紊乱或复杂综合征的一部分。基因突变可以解释甲状旁腺形成疾病、甲状旁腺激素合成或分泌失调以及甲状旁腺破坏。多年来，许多不同的选择可用于治疗不同类型的甲状旁腺疾病。治疗选择包括手术切除分泌过多的甲状旁腺组织，给予甲状旁腺激素、维生素D、活化维生素D、钙、磷酸盐结合剂、钙感应受体和维生素D受体激活剂等。甲状旁腺激素的准确评估也为正确诊断甲状旁腺疾病提供了必要的生化信息。由于截断的甲状旁腺激素片段、甲状旁腺激素磷酸化和甲状旁腺激素氨基酸氧化的干扰，目前可用的免疫测定可能会高估或低估甲状旁腺激素的生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.