Association between dehydroepiandrosterone levels and cardiovascular risk in public sector health workers in a Peruvian region.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-06-19 eCollection Date: 2021-03-01 DOI:10.1097/XCE.0000000000000219

Ricardo J Rojas, Janett V Chávez-Sosa, Rosmery Gutierrez-Ajalcriña, Salomón Huancahuire-Vega

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Abstract

Alterations in dehydroepiandrosterone sulfate (DHEAS) levels have been shown to affect the cardiovascular system. This study examined the associations between DHEAS levels and cardiovascular risk in workers of a public hospital in Lima, Peru. The analytical cross-sectional study was conducted at the Hospital de Huaycán, Peru. The cardiovascular risk was assessed in health workers using the Framingham score and categorized into high and low cardiovascular risk groups, and then the DHEAS levels of both groups were compared. Two hundred ninety-six health workers were studied, 67.2% showed low cardiovascular risk, 22.3% intermediate and 10.5% high. DHEAS levels were lower in the high cardiovascular risk group (2156.9 vs 2814.6 ng/mL; P < 0.05) and showed negative association (prevalence rate ratio 0.14, 95% IC 0.04-0.53; P < 0.05) in multivariable analysis (P < 0.05). DHEAS, glycosylated hemoglobin, pulse pressure and mean arterial pressure show an independent association with high cardiovascular risk in a group of health workers. Additional variables should be considered for cardiovascular risk assessment.

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秘鲁地区公共部门卫生工作者脱氢表雄酮水平与心血管风险之间的关系

硫酸脱氢表雄酮(DHEAS)水平的改变已被证明会影响心血管系统。本研究调查了秘鲁利马一家公立医院工作人员DHEAS水平与心血管风险之间的关系。分析性横断面研究是在秘鲁Huaycán医院进行的。采用Framingham评分对卫生工作者的心血管风险进行评估，并将其分为心血管风险高组和低组，然后比较两组的DHEAS水平。对296名卫生工作者进行了研究，67.2%为低心血管风险，22.3%为中等风险，10.5%为高风险。高心血管风险组DHEAS水平较低(2156.9 vs 2814.6 ng/mL;p p p

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.