Medicinal Inula Species: Phytochemistry, Biosynthesis, and Bioactivities.

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

American Journal of Chinese Medicine Pub Date : 2021-01-01 Epub Date: 2021-02-20 DOI:10.1142/S0192415X21500166

Cheng-Peng Sun, Zi-Li Jia, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Chao Wang, Bao-Jing Zhang, Wen-Yu Zhao, Xiao-Chi Ma

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引用次数: 9

Abstract

As a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary metabolites, including several known natural products that were isolated for the first time from the genus Inula. Most of them exhibited potential bioactivities in various diseases. The review aimed to summarize the advance of recent researches (2010-2020) on phytochemical constituents, biosynthesis, and pharmacological properties of the genus Inula for providing a scientific basis and supporting its application and exploitation for new drug development.

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药用菊属:植物化学、生物合成和生物活性。

菊属作为菊科的一个属，在世界各地广泛分布，其中一些被用于传统药物。从菊属植物中分离出许多代谢物，其中一些已显示出具有一定范围的药理活性。菊属植物含有丰富的倍半萜类化合物，如菊烷、黄烷、倍半萜类二聚体和三聚体。此外，菊属植物中还含有其他类型的萜类化合物、黄酮类化合物和木质素。自2010年以来，发现了300多种新的次生代谢物，其中包括首次从菊属植物中分离到的几种已知天然产物。其中大部分在多种疾病中表现出潜在的生物活性。本文综述了近年来在菊属植物化学成分、生物合成和药理特性等方面的研究进展，为其在新药开发中的应用和开发提供科学依据。

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来源期刊

American Journal of Chinese Medicine 医学-全科医学与补充医学

CiteScore

9.90

自引率

8.80%

发文量

159

审稿时长

4.5 months

期刊介绍： The American Journal of Chinese Medicine, which is defined in its broadest sense possible, publishes original articles and essays relating to traditional or ethnomedicine of all cultures. Areas of particular interest include: Basic scientific and clinical research in indigenous medical techniques, therapeutic procedures, medicinal plants, and traditional medical theories and concepts; Multidisciplinary study of medical practice and health care, especially from historical, cultural, public health, and socioeconomic perspectives; International policy implications of comparative studies of medicine in all cultures, including such issues as health in developing countries, affordability and transferability of health-care techniques and concepts; Translating scholarly ancient texts or modern publications on ethnomedicine. The American Journal of Chinese Medicine will consider for publication a broad range of scholarly contributions, including original scientific research papers, review articles, editorial comments, social policy statements, brief news items, bibliographies, research guides, letters to the editors, book reviews, and selected reprints.