Modification of oncolytic adenovirus and its application in cancer therapy.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Discovery medicine Pub Date : 2020-11-01

Yin Liang, Jian He, Yongxiang Zhao

引用次数: 0

Abstract

Oncolytic virus refers to a type of virus that can replicate in tumor cells and eventually lyse them. Oncolytic adenoviruses are widely used because of their acceptable safety, but they are also limited in their clinical applications due to their own limitations. Therefore, the adenovirus is modified in multiple ways to improve the safety of the treatment, enhance the impact of oncolysis, and reduce the effect of neutralizing antibodies on the virus. The combined application of oncolytic adenovirus and other drugs plays a synergistic role in the treatment of tumors.

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溶瘤腺病毒的修饰及其在肿瘤治疗中的应用。

溶瘤病毒是指一种能够在肿瘤细胞中复制并最终溶解肿瘤细胞的病毒。溶瘤腺病毒因其可接受的安全性而被广泛应用，但其自身的局限性也限制了其临床应用。因此，通过多种途径对腺病毒进行修饰，以提高治疗的安全性，增强溶瘤作用，减少中和抗体对病毒的影响。溶瘤腺病毒与其他药物联合应用，在肿瘤治疗中发挥协同作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.