Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (Papio anubis).

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Comparative medicine Pub Date : 2021-04-01 Epub Date: 2021-02-12 DOI:10.30802/AALAS-CM-20-000068

Erin L Willis, Richard Eberle, Roman F Wolf, Gary L White, Dianne McFarlane

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引用次数: 1

Abstract

Aging of the immune system is characterized by the loss of naïve T-cells, increased inflammation, and immune function impairment. Chronic infection with cytomegalovirus is thought to play a role in age-related changes in immunity. Therefore, to assess the effect of pathogens such as cytomegalovirus on the immune system, we determined lymphocyte populations and inflammatory markers over a 3-y period in captive, middle-age baboons, with various exposure to pathogens and shedding pressure. Groups included SPF (i.e., pathogen-negative; n = 14); large-group, conventionally housed (CONV LG; pathogen- positive; n = 14), and small-group, conventionally housed (CONV SM; pathogen-positive; n = 7). All baboon groups showed a decrease in CD45RA+ CD28+ (i.e., naive) cells over time during middle age, but the rate of decline appeared faster in CONV LG baboons than in the other groups. In addition, the reduction in CD45RA+ CD28+ cells in the CONV LG baboons coincided with higher IgG levels against baboon cytomegalovirus, increased serum cortisol concentration, and a greater inflammatory phenotype. The results of this project support a role for cytomegalovirus infection in immune system alterations in middle-aged baboons.

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慢性病毒感染对中年狒狒淋巴细胞群的影响。

免疫系统老化的特征是naïve t细胞的丧失、炎症的增加和免疫功能的损害。慢性巨细胞病毒感染被认为在与年龄相关的免疫变化中起作用。因此，为了评估病原体(如巨细胞病毒)对免疫系统的影响，我们对圈养的中年狒狒进行了为期3年的淋巴细胞数量和炎症标志物测定，这些狒狒暴露于不同的病原体和脱落压力下。分组包括SPF(即病原体阴性);N = 14);大组，常规安置(CONV LG;病原体——积极;n = 14)，小组常规饲养(CONV SM;pathogen-positive;n = 7)。在中年时期，所有狒狒组的CD45RA+ CD28+(即幼稚)细胞随着时间的推移而减少，但CONV LG狒狒的下降速度比其他组快。此外，CONV LG狒狒中CD45RA+ CD28+细胞的减少与抗狒狒巨细胞病毒的IgG水平升高、血清皮质醇浓度升高和更大的炎症表型相吻合。本项目的结果支持巨细胞病毒感染在中年狒狒免疫系统改变中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comparative medicine 医学-动物学

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.