Association between rs1421085 and rs9939609 Polymorphisms of Fat Mass and Obesity-Associated Gene with High-Density Lipoprotein Cholesterol and Triglyceride in Obese Turkish Children and Adolescents.

IF 0.4 Q4 PEDIATRICS

Journal of pediatric genetics Pub Date : 2021-03-01 Epub Date: 2020-06-10 DOI:10.1055/s-0040-1713154

Nihal Inandiklioğlu, Adem Yaşar

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引用次数: 6

Abstract

Several studies have shown that rs9939609 and rs1421085 in fat mass and obesity-associated ( FTO ) gene rs17782313 and rs12970134 in melanocortin-4 receptor ( MC4R ) gene influence obesity. In the present study, we aimed to determine association between rs9939609, rs1421085, rs17782313, and rs12970134 polymorphism, and their relation with body mass index (BMI), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and lipid values in obese children. We included 100 newly diagnosed obese children and 100 healthy children. The rs1421085 (CC/CT) ( p = 0.019) and rs9939609 (AA/AT) ( p = 0.002) polymorphism regions were higher in the obese group. Additionally, we found that both the rs1421085 (CC/CT) and rs9939609 (AA/AT) polymorphism associated with high-density lipoprotein cholesterol ( p = 0.011 and p = 0.003) and triglycerides ( p = 0.01 and p = 0.004) level, respectively. Further, the rs9939609 and rs1421085 variants of FTO gene associated with HDL-cholesterol and triglycerides levels in obese children; however, updated studies with a large sample size are required to establish strong links with genetic variants and risk factors in childhood obesity.

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肥胖土耳其儿童和青少年脂肪量和肥胖相关基因rs1421085和rs9939609多态性与高密度脂蛋白胆固醇和甘油三酯的关系

多项研究表明，脂肪量与肥胖相关(FTO)基因rs9939609和rs1421085的rs17782313和rs12970134的黑素皮质素-4受体(MC4R)基因影响肥胖。在本研究中，我们旨在确定rs9939609、rs1421085、rs17782313和rs12970134多态性与肥胖儿童体重指数(BMI)、葡萄糖、胰岛素、胰岛素抵抗稳态模型评估(HOMA-IR)和脂质值的关系。我们纳入了100名新诊断的肥胖儿童和100名健康儿童。肥胖组rs1421085 (CC/CT) (p = 0.019)和rs9939609 (AA/AT) (p = 0.002)多态性较高。此外，我们发现rs1421085 (CC/CT)和rs9939609 (AA/AT)多态性分别与高密度脂蛋白胆固醇(p = 0.011和p = 0.003)和甘油三酯(p = 0.01和p = 0.004)水平相关。此外，肥胖儿童中与hdl -胆固醇和甘油三酯水平相关的FTO基因rs9939609和rs1421085变异;然而，需要更大样本量的最新研究来确定遗传变异和儿童肥胖风险因素之间的密切联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of pediatric genetics PEDIATRICS-

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期刊介绍： The Journal of Pediatric Genetics is an English multidisciplinary peer-reviewed international journal publishing articles on all aspects of genetics in childhood and of the genetics of experimental models. These topics include clinical genetics, molecular genetics, biochemical genetics, medical genetics, dysmorphology, teratology, genetic counselling, genetic engineering, formal genetics, neuropsychiatric genetics, behavioral genetics, community genetics, cytogenetics, hereditary or syndromic cancer genetics, genetic mapping, reproductive genetics, fetal pathology and prenatal diagnosis, multiple congenital anomaly syndromes, and molecular embryology of birth defects. Journal of Pediatric Genetics provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis of childhood genetics. Journal of Pediatric Genetics encourages submissions from all authors throughout the world. The following articles will be considered for publication: editorials, original and review articles, short report, rapid communications, case reports, letters to the editor, and book reviews. The aim of the journal is to share and disseminate knowledge between all disciplines in the field of pediatric genetics. This journal is a publication of the World Pediatric Society: http://www.worldpediatricsociety.org/ The Journal of Pediatric Genetics is available in print and online. Articles published ahead of print are available via the eFirst service on the Thieme E-Journals platform.