Prediabetes versus type 2 diabetes mellitus based on pre-percutaneous coronary intervention thrombolysis in myocardial infarction flow grade in patients with ST-segment elevation myocardial infarction after successful newer-generation drug-eluting stent implantation.

IF 2.8 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes & Vascular Disease Research Pub Date : 2021-01-01 DOI:10.1177/1479164121991505

Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seunghwan Kim, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang

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引用次数: 2

Abstract

Background: We compared the 2-year clinical outcomes between prediabetes and type 2 diabetes mellitus (T2DM) according to the pre-percutaneous coronary intervention (PCI) thrombolysis in myocardial infarction (TIMI) flow grade in patients with ST-segment elevation myocardial infarction.

Methods: Overall, 6448 STEMI patients were divided into two groups: pre-PCI TIMI 0/1 group (n = 4854) and pre-PCI TIMI 2/3 group (n = 1594). They were further divided into patients with normoglycemia, prediabetes, and T2DM. The major endpoint was major adverse cardiac events (MACEs), defined as all-cause death, recurrent myocardial infarction, or any repeat revascularization.

Results: In the pre-PCI TIMI 0/1 group, all-cause death rate was higher in both prediabetes (adjusted hazard ratio [aHR]: 1.633, p = 0.045) and T2DM (aHR: 2.064, p = 0.002) groups than in the normoglycemia group. In the pre-PCI TIMI 2/3 group, any repeat revascularization rate was also higher in both prediabetes (aHR: 2.511, p = 0.039) and T2DM (aHR: 3.156, p = 0.009) than normoglycemia. In each group (pre-PCI TIMI 0/1 or 2/3), the MACEs and all other clinical outcomes rates were similar between the prediabetes and T2DM groups.

Conclusions: Prediabetes showed comparable worse clinical outcomes to those of T2DM regardless of the pre-PCI TIMI flow grade.

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新一代药物洗脱支架置入术成功后st段抬高型心肌梗死患者经皮冠状动脉介入溶栓对心肌梗死血流等级的影响:前驱糖尿病vs 2型糖尿病

背景:我们根据st段抬高型心肌梗死患者经皮冠状动脉介入治疗(PCI)溶栓治疗(TIMI)血流分级，比较了2型糖尿病(T2DM)患者2年的临床结果。方法:6448例STEMI患者分为两组:pci前TIMI 0/1组(n = 4854)和pci前TIMI 2/3组(n = 1594)。他们进一步分为血糖正常、糖尿病前期和2型糖尿病患者。主要终点是主要心脏不良事件(mace)，定义为全因死亡、复发性心肌梗死或任何重复血运重建术。结果:pci前TIMI 0/1组糖尿病前期(校正危险比[aHR]: 1.633, p = 0.045)和T2DM组的全因死亡率均高于血糖正常组(aHR: 2.064, p = 0.002)。在pci前TIMI 2/3组中，糖尿病前期(aHR: 2.511, p = 0.039)和T2DM (aHR: 3.156, p = 0.009)的任何重复血运重建率均高于血糖正常者。在每组(pci前TIMI 0/1或2/3)中，糖尿病前期和T2DM组之间的mace和所有其他临床转归率相似。结论:无论pci前TIMI血流等级如何，前驱糖尿病的临床结果都比T2DM差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Vascular Disease Research ENDOCRINOLOGY & METABOLISM-PERIPHERAL VASCULAR DISEASE

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Diabetes & Vascular Disease Research is the first international peer-reviewed journal to unite diabetes and vascular disease in a single title. The journal publishes original papers, research letters and reviews. This journal is a member of the Committee on Publication Ethics (COPE)