Toxicity studies of perfluoroalkyl carboxylates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).

Abstract

Widespread exposure to several per/polyfluorinated alkyl substances (PFAS) is associated with a wide array of toxicities. The National Toxicology Program (NTP) conducted 28-day toxicity studies in male and female Sprague Dawley (Hsd:Sprague Dawley SD) rats (n = 10/dose; five doses) to compare the toxicities of seven PFAS chemicals (three sulfonic acids or salt: perfluorobutane sulfonic acid, perfluorohexane sulfonate potassium salt, and perfluorooctane sulfonic acid; and four carboxylates: perfluorohexanoic acid [PFHxA], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], and perfluorodecanoic acid [PFDA]) via gavage in deionized water with 2% Tween 80. This report describes the studies of the four carboxylates (PFHxA, PFOA, PFNA, and PFDA); a companion report (NTP Toxicity Study Report 96) describes the studies of the three PFAS sulfonates. Doses were 0 to 1,000 mg/kg/day for PFHxA, 0 to 10 mg/kg/day for PFOA males, 0 to 100 mg/kg/day for PFOA females, 0 to 10 mg/kg/day for PFNA males, 0 to 25 mg/kg/day for PFNA females, and 0 to 2.5 mg/kg/day for PFDA. (Abstract Abridged).