Toxicity studies of 1020 Long Multiwalled Carbon Nanotubes (L-MWNT-1020) administered by inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.

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Abstract

Multiwalled carbon nanotubes (MWCNTs) are highly ordered hexagonal lattices of carbon atoms arranged into cylinders by hydrogen bonding, dipolar forces, hydrophilic or hydrophobic interactions, gravity, and other forces. MWCNTs are synthesized by applying energy to a carbon source, which produces individual or groups of carbon atoms that reassemble into tubes. One of the primary uses of MWCNTs is in nanotube-reinforced polymer composite materials that take advantage of their low-density and high load-bearing capacity. Nanoscale materials were nominated by the Rice University Center for Biological and Environmental Nanotechnology to the National Toxicology Program for toxicologic testing. Because long-term inhalation toxicity and carcinogenicity studies were being conducted on a relatively short, rigid MWCNT, a representative long and thin MWCNT was selected for these studies. Following an evaluation of 24 different long, thin MWCNTs, the 1020 Long Multiwalled Carbon Nanotube (L-MWNT-1020) (Sun Innovations, Fremont, CA) was selected for study based on availability, high purity (97%), and the low amount of residual nickel catalyst (0.52% by weight). The average L-MWNT-1020 nanotube length was 2,600 nm and the average width was 15.3 nm. Because nickel was shown to be tightly bound to L-MWNT-1020, tissue nickel content was measured to determine lung burden. (Abstract Abridged).

通过吸入给 Sprague Dawley (Hsd:Sprague Dawley SD) 大鼠和 B6C3F1/N 小鼠施用 1020 长多壁碳纳米管(L-MWNT-1020)的毒性研究。
多壁碳纳米管(MWCNT)是由碳原子通过氢键、双极力、亲水或疏水相互作用、重力和其他力量排列成圆柱体的高度有序的六边形晶格。MWCNT 是通过对碳源施加能量合成的,能量产生的单个或多个碳原子重新组合成管状。MWCNTs 的主要用途之一是利用其低密度和高承载能力的纳米管增强聚合物复合材料。纳米级材料由莱斯大学生物与环境纳米技术中心提名给国家毒理学计划进行毒理学测试。由于长期吸入毒性和致癌性研究是在相对较短的硬质 MWCNT 上进行的,因此这些研究选择了具有代表性的细长 MWCNT。在对 24 种不同的细长 MWCNT 进行评估后,根据其可用性、高纯度(97%)和低残留镍催化剂量(0.52%(按重量计)),选择了 1020 长多壁碳纳米管(L-MWNT-1020)(Sun Innovations,加利福尼亚州弗里蒙特)进行研究。L-MWNT-1020 纳米管的平均长度为 2,600 纳米,平均宽度为 15.3 纳米。由于镍被证明与 L-MWNT-1020 紧密结合,因此测量了组织中的镍含量,以确定肺负荷。(摘要有删节)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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