Morphological changes in adrenal cortex--the final effect of angiotensin II receptor antagonists.

Teresa Masłyk, Jadwiga Romanowska-Sarlej, Ewa Kifer-Wysocka, Włodzimierz Matysiak, Krystyna Czerny
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Abstract

The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex. After a 2-month break in drug administration, the reconstruction of glandular cells was noticed, which could indicate that the observed changes are of transitory character.

肾上腺皮质形态学改变——血管紧张素受体拮抗剂的最终效果。
观察氯沙坦、血管紧张素受体对大鼠肾上腺肾小球层组织学图像的影响。该药物以治疗剂量和十倍高剂量施用。表现为腺体细胞减少,皮层胚性细胞增多。停药2个月后,观察到腺细胞的重建,说明所观察到的变化是暂时性的。
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