The influence of a single dose of adriamycin on the pregnant rat female liver-histological and histochemical evaluation.

Abstract

The purpose of the study was histological evaluation of the liver of a pregnant rat, which 4 weeks before planned pregnancy was administered adriamycin intraperitoneally in a dose of 5 mg/kg of body weight. Focal damage of hepatocytes ("naked nuclei" which were the evidence of cell damage) were observed in histological preparations. Significant steatosis and vessel damage were visible as well. Around the central vein and in portocholangial space numerous ductules spuriae appear.