Histomorphology of renal corpuscles of kidney of experimental animals after Cladribine (2-CdA) administration.

Abstract

The renal corpuscles of the kidney of white Wistar rats was examined. The animals were given Cladribine (2-CdA) subcutaneously at the dosages of 0.07 mg/kg b.w./24 h for 7 days and 0.1 mg/kg b.w./24 h for 6 days in 3 courses with 5 weeks' break between each. The animals were killed in each instance, 24 hours after the last dose of the drug and 4 weeks after the last dose. The kidney samples were taken for histological and histochemical examination, then stained with hematoxylin and eosin, using the Masson's, PAS, and Feulgen's methods. In all of the groups, changes were observed but the intensity differed, with widening or narrowing of the urinary space, thickening of the basement membrane of the parietal layer of the Bowman's capsule and the basement membrane of capillaries, and density changes in capillary vessels. Hyperaemia in renal glomeruli and in all parenchyma, and infiltrations around the tubules and renal glomeruli, were also observed.