Water transport into bile and role in bile formation.

Giuseppe Calamita, Domenico Ferri, Patrizia Gena, Giuseppa E Liquori, Raúl A Marinelli, Giuliano Meyer, Piero Portincasa, Maria Svelto
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Abstract

Formation of bile and generation of bile flow are driven by the active secretion of bile salts (BS), lipids and electrolytes into the canalicular and bile duct lumens followed by the osmotic movement of water. Although the transporting proteins involved in solute secretion have been cloned and their coordinated interplay defined both in health and disease, boosted by the discovery of the aquaporin water channels, only recently has considerable attention been addressed to the mechanism by which water, the major component of bile (> 95%), moves across the hepatobiliary epithelia. This review summarizes the novel acquisitions in liver membrane water transport and functional participation of aquaporin water channels in multiple aspects of hepatobiliary fluid balance. Emerging evidences suggesting involvement of aquaporins in the metabolic homeostasis of the hepatobiliary tract are also discussed.

水进入胆汁和在胆汁形成中的作用。
胆汁的形成和胆汁流的产生是由胆汁盐(BS)、脂质和电解质主动分泌到小管和胆管腔内,然后是水的渗透运动驱动的。尽管参与溶质分泌的转运蛋白已经被克隆出来,并且它们在健康和疾病中都有协调的相互作用,但由于水通道蛋白水通道的发现,直到最近人们才开始关注作为胆汁主要成分(> 95%)的水通过肝胆上皮的机制。本文综述了肝膜水转运的新进展以及水通道蛋白在肝胆液平衡多个方面的功能参与。新出现的证据表明,水通道蛋白参与代谢稳态的肝胆道也进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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