[Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese].

Xiao-Ling Wang, Zhong-Jie Fan, Jian-Feng Huang, Shao-Yong Su, Jian-Gong Zhao, Dong-Feng Gu
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Abstract

An extensive association analysis of PON gene cluster (PONs) with coronary heart disease (CHD) was performed in Chinese Han population. Eleven polymorphisms of PON1, PON2 and PON3 gene were investigated for association with CHD in 474 male patients and 475 controls. Univariate analyses showed the cases had significantly higher frequencies of PON1 192Q allele, 160R allele, -162A allele and PON2 311C allele than were seen in the controls. Logistic regression analyses revealed only the PON1 R160G and -162G/A polymorphisms remained significantly associated with CHD (P = 0.0054 and P = 0.0002). Haplotype analyses for various polymorphism combinations further confirmed the results of individual polymorphism analyses. Only the frequencies of haplotypes containing -162A allele were significantly higher,whereas only the frequencies of haplotypes containing 160G allele significantly lower in cases than those in controls in various polymorphism combinations. This extensive association study has identified the PON1 -162G/A and R160G polymorphisms to be independently associated with CHD in Chinese Han population,and warrants further study to elucidate the biological mechanism.

中国人PON基因簇多态性与冠心病的相关性分析
对中国汉族人群PON基因簇(PONs)与冠心病(CHD)的相关性进行了广泛的分析。研究了474名男性患者和475名对照者的11个PON1、PON2和PON3基因多态性与冠心病的关系。单因素分析显示,这些病例的PON1 192Q等位基因、160R等位基因、-162A等位基因和PON2 311C等位基因频率显著高于对照组。Logistic回归分析显示,只有PON1 R160G和-162G/A多态性与冠心病存在显著相关性(P = 0.0054和P = 0.0002)。各种多态性组合的单倍型分析进一步证实了个体多态性分析的结果。在各种多态性组合中,只有含有-162A等位基因的单倍型频率显著高于对照组,而只有含有160G等位基因的单倍型频率显著低于对照组。这项广泛的关联研究已经确定了PON1 -162G/A和R160G多态性与中国汉族人群冠心病的独立相关,值得进一步研究以阐明其生物学机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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