QSAR modeling on dopamine D2 receptor binding affinity of 6-methoxy benzamides

Abstract

QSAR modeling was performed on 58 (S) N-[(1-ethyl-2-pyrrolidinyl) methyl]-6-methoxy benzamides as dopamine (DA) D₂ receptor antagonists to identify the structural requirements for DA D₂ receptor binding affinity. The study pointed out that the presence of hydrophobic substituents at R₃ position and electron-donating groups at R₅ position increased the biological activity. Substitutions at phenyl ring favored the binding affinity of these benzamides. Ethyl group and iodine at R₃ position were advantageous to the activity whereas nitro group at phenyl ring hindered the antagonistic activity.