NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane (2-BP).

NTP CERHR MON Pub Date : 2003-12-01

{"title":"NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 2-Bromopropane (2-BP).","authors":"","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for 2-bromopropane to cause adverse effects on reproduction and development in humans. 2-Bromopropane was selected for evaluation due to documented evidence of worker exposures and published evidence of reproductive toxicity in both rodents and humans. 2-Bromopropane may be used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic chemicals. In Asia, 2-bromopropane was also used as a replacement for chlorofluorocarbons and 1,1,1-trichloroethane, and is used as a solvent/cleaner for microelectronics. The results of this evaluation on 2-brompropane are published in a NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of 2-Bromopropane, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to 2-bromopropane on human development and reproduction. No data were available on environmental exposure of the general public to 2-bromopropane. However, occupational exposure data indicate workplace exposures to 2-bromopropane range from </=0.004- 1.35 ppm. Conclusions were based on the available occupational exposure data and on studies in humans and laboratory animals. First, there is some concern for adverse reproductive effects when people are exposed to concentrations of 2-bromopropane at the high end of the occupational exposure range, and minimal concern at the low end of the exposure range. These conclusions are supported by toxicity in rats at 100 ppm exposures and adverse reproductive effects in occupationally exposed humans. Second, there is insufficient evidence to assess the developmental effects of 2-bromopropane exposure. These conclusions are based on occupational exposure data which do not account for dermal contact with 2-bromopropane. NTP-CERHR monographs are transmitted to federal and state agencies, interested parties, and the public and are available in electronic PDF format on the CERHR web site (http://cerhr.niehs.nih.gov) and in printed text or CD-ROM from the CERHR (National Institute of Environmental Health Sciences, P.O. Box 12233, MD EC-32, Research Triangle Park, NC; fax: 919-316-4511).</p>","PeriodicalId":87200,"journal":{"name":"NTP CERHR MON","volume":" 10","pages":"i-III11"},"PeriodicalIF":0.0000,"publicationDate":"2003-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"NTP CERHR MON","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an evaluation of the potential for 2-bromopropane to cause adverse effects on reproduction and development in humans. 2-Bromopropane was selected for evaluation due to documented evidence of worker exposures and published evidence of reproductive toxicity in both rodents and humans. 2-Bromopropane may be used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic chemicals. In Asia, 2-bromopropane was also used as a replacement for chlorofluorocarbons and 1,1,1-trichloroethane, and is used as a solvent/cleaner for microelectronics. The results of this evaluation on 2-brompropane are published in a NTP-CERHR monograph which includes: 1) the NTP Brief, 2) the Expert Panel Report on the Reproductive and Developmental Toxicity of 2-Bromopropane, and 3) public comments received on the Expert Panel Report. As stated in the NTP Brief, the NTP reached the following conclusions regarding the possible effects of exposure to 2-bromopropane on human development and reproduction. No data were available on environmental exposure of the general public to 2-bromopropane. However, occupational exposure data indicate workplace exposures to 2-bromopropane range from

本刊更多论文

NTP-CERHR专著:2-溴丙烷(2-BP)对人类生殖和发育的潜在影响。

国家毒理学计划(NTP)人类生殖风险评估中心(CERHR)对2-溴丙烷对人类生殖和发育造成不利影响的可能性进行了评估。选择2-溴丙烷进行评估，是因为有文件证据表明工人接触该物质，并有已发表的证据表明该物质对啮齿动物和人类都有生殖毒性。2-溴丙烷可用作合成药物、染料和其他有机化学品的中间体。在亚洲，2-溴丙烷还被用作氯氟烃和1,1,1-三氯乙烷的替代品，并被用作微电子的溶剂/清洁剂。对2-溴丙烷的评估结果发表在NTP- cerhr专著中，其中包括:1)NTP简报，2)2-溴丙烷生殖和发育毒性专家小组报告，以及3)专家小组报告收到的公众意见。正如国家毒理学规划概要所述，国家毒理学规划就接触2-溴丙烷对人类发育和生殖可能产生的影响得出以下结论。没有关于公众在环境中暴露于2-溴丙烷的数据。然而，职业暴露数据表明，工作场所暴露于2-溴丙烷的范围从

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

NTP CERHR MON

自引率

0.00%

发文量