Tomas Vanek, Zbynek Straka, Jakub Hrabak, Martin Jares, Peter Jan Brucek, Jan Votava
{"title":"Use of recombinant activated factor VII in cardiac surgery for an effective treatment of severe intractable bleeding.","authors":"Tomas Vanek, Zbynek Straka, Jakub Hrabak, Martin Jares, Peter Jan Brucek, Jan Votava","doi":"10.1536/jhj.45.855","DOIUrl":null,"url":null,"abstract":"<p><p>Experience gained with administration of supranormal-therapeutic doses (90 microg/kg) of recombinant activated factor VII in 7 cardiac surgery patients is presented. The patients were given recombinant activated factor VII postoperatively for intractable bleeding, 5 of them after surgical revision. Administration of recombinant activated factor VII was associated with significant reduction in blood loss (P < 0.05) and shortening of INR and aPTT in laboratory tests. None of the patients needed reoperation. Administration of recombinant activated factor VII proved highly effective in management of massive hemorrhage in cardiac surgery.</p>","PeriodicalId":14717,"journal":{"name":"Japanese heart journal","volume":"45 5","pages":"855-60"},"PeriodicalIF":0.0000,"publicationDate":"2004-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"30","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese heart journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1536/jhj.45.855","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 30
Abstract
Experience gained with administration of supranormal-therapeutic doses (90 microg/kg) of recombinant activated factor VII in 7 cardiac surgery patients is presented. The patients were given recombinant activated factor VII postoperatively for intractable bleeding, 5 of them after surgical revision. Administration of recombinant activated factor VII was associated with significant reduction in blood loss (P < 0.05) and shortening of INR and aPTT in laboratory tests. None of the patients needed reoperation. Administration of recombinant activated factor VII proved highly effective in management of massive hemorrhage in cardiac surgery.
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