The ultrastructure of the nasal polyps in patients with and without cystic fibrosis.

D Beju, W D Meek, J C Kramer
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Abstract

Nasal polyps are commonly associated with cystic fibrosis (CF) and also with idiopathic allergies, asthma, and aspirin intolerance. The pathogenesis of nasal polyp formation is controversial. The present study investigates the ultrastructure of thirteen nasal polyps surgically removed from seven CF patients and six non-CF (NCF) patients with allergic diseases, asthma, and aspirin intolerance. All nasal polyps showed focal edema, hyperplasia, atrophy, or squamous metaplasia of the epithelium. The lamina propria was moderately populated with small blood vessels and mucous glands and showed focal accumulation of inflammatory cells. The CF nasal polyps, however, revealed several specific characteristics: 1) minimal damage to the surface epithelium, 2) presence of a mucus blanket lining the apical epithelium, 3) occasional intracytoplasmic lumens, 4) continuous and fenestrated type capillaries, 5) numerous degranulated mast cells, 6) many plasma cells, often with atypical morphology and intracisternal Russell bodies, and 7) a smaller number of eosinophils as compared to the NCF nasal polyps. The results indicate significant differences between CF and NCF nasal polyps and support the multifactorial pathways theory of nasal polyp formation.

有无囊性纤维化患者鼻息肉的超微结构。
鼻息肉通常与囊性纤维化(CF)有关,也与特发性过敏、哮喘和阿司匹林不耐受有关。鼻息肉形成的发病机制存在争议。本研究探讨了从7例CF患者和6例非CF (NCF)患者手术切除的13个鼻息肉的超微结构,这些患者伴有过敏性疾病、哮喘和阿司匹林不耐受。所有鼻息肉均表现为局灶性水肿、增生、萎缩或上皮鳞状化生。固有层有小血管和粘液腺体,并有局灶性炎症细胞积聚。然而,CF型鼻息肉显示出几个特定的特征:1)表面上皮损伤最小,2)顶端上皮内存在粘液层,3)偶尔存在胞浆内腔,4)连续和开窗型毛细血管,5)大量脱颗粒肥大细胞,6)许多浆细胞,通常具有非典型形态和胸壁内罗素小体,7)与NCF型鼻息肉相比,嗜酸性粒细胞数量较少。结果表明CF型鼻息肉与NCF型鼻息肉存在显著差异,支持鼻息肉形成的多因子通路理论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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