Immunomodulatory function of the 5-HT3 receptor antagonist tropisetron.

Scandinavian journal of rheumatology. Supplement Pub Date : 2004-01-01

E M Schneider, X Ma, T Stratz, W Müller, I Lorenz, W D Seeling

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Abstract

Objective: To characterize the immune modulatory effects of 5-HT3 receptor antagonist treatment in patients with fibromyalgia, autoimmune disorders, and chronic pain.

Methods: Multiplex-assisted cytokine measurements were performed before and during treatment. Whole blood stimulation with TNF-alpha was carried out to determine the proinflammatory response induced by exogenous TNF-alpha.

Results: Five of nine patients clinically responded to treatment, and two had a moderate response. All patients had significantly elevated levels of T-H1 cytokines more prominent than TNF-alpha, IL-1beta, and IL-6. Treatment resulted in transient effects on peripheral monocyte counts in all but one patient, a plasma IL-1beta increase in two responder patients, and decreased T-H1 cytokines in two responder patients. Ex vivo TNF-alpha stimulation was transiently reconstituted in three responder patients to a significant level. Three patients showed a marginal reconstitutive response.

Conclusion: 5-HT3 receptor blockade transiently affects monocyte tissue infiltration, modulates T-H1 cytokines in clinical responders as well as MIP-1beta in moderate responders, and transiently affects the ex vivo response to exogenous TNF-alpha.

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5-HT3受体拮抗剂托烷司琼的免疫调节功能。

目的:探讨5-HT3受体拮抗剂对纤维肌痛、自身免疫性疾病和慢性疼痛患者的免疫调节作用。方法:在治疗前和治疗中进行多种辅助细胞因子测定。用tnf - α刺激全血以测定外源性tnf - α诱导的促炎反应。结果:9例患者中5例对治疗有临床反应，2例有中度反应。所有患者的T-H1细胞因子水平均显著升高，且高于tnf - α、il -1 β和IL-6。除一名患者外，治疗对所有患者的外周血单核细胞计数产生短暂影响，两名有反应的患者血浆il -1 β升高，两名有反应的患者T-H1细胞因子降低。体外tnf - α刺激在三名有反应的患者中短暂地恢复到显著水平。3例患者出现边缘性重构反应。结论:5-HT3受体阻断可短暂影响单核细胞组织浸润，在临床应答者中可调节T-H1细胞因子，在中度应答者中可调节mip -1 β，并可短暂影响对外源性tnf - α的体外应答。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Scandinavian journal of rheumatology. Supplement

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