Neutrophils are active in total joint implant loosening.

Acta orthopaedica Scandinavica Pub Date : 2004-10-01 DOI:10.1080/00016470410001402

Waldemar Wozniak, Jacek Markuszewski, Malgorzata Wierusz-Kozlowska, Henryk Wysocki

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引用次数: 9

Abstract

Background: Polymorphonuclear neutrophils (PMN) are the first cells to take part in the local foreign body reaction in aseptic loosening of endoprostheses. The aim of this study was to evaluate the systemic host reaction to total joint replacement by measuring the production of nitric oxide by neutrophils before and after total joint replacement.

Patients and method: Blood samples were collected from 33 patients (27 hips and 6 knees) before surgery, and 2 weeks, 2 months and 2.5-3 years after surgery. The levels of nitric oxide produced by PMN were measured by the method described by Markert et al. (1994).

Results: Patients reporting pain in the region of the implant 3 years after surgery, and also patients with radiographic signs of loosening, had higher production of NO in the early period and 3 years after the implantation than those with good clinical results.

Interpretation: We propose that elevated levels of nitric oxide production by PMNs may serve as a marker of total joint prosthesis loosening.

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中性粒细胞在全关节植入物松动中是活跃的。

背景:多形核中性粒细胞(PMN)是在假体无菌松动中最先参与局部异物反应的细胞。本研究的目的是通过测量全关节置换术前后中性粒细胞一氧化氮的产生来评估全身宿主对全关节置换术的反应。患者与方法:术前、术后2周、2个月、2.5 ~ 3年采集33例患者(27髋、6膝)的血液标本。PMN产生的一氧化氮水平是用Markert等人(1994)描述的方法测量的。结果:术后3年报告种植体区域疼痛的患者，以及有影像学松动迹象的患者，在种植体早期和种植体后3年的NO分泌量高于临床效果良好的患者。解释:我们认为pmn产生的一氧化氮水平升高可能是关节假体松动的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Acta orthopaedica Scandinavica

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