New therapeutic strategies in perinatal stroke.

W Balduini, S Carloni, E Mazzoni, M Cimino
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引用次数: 26

Abstract

Perinatal stroke represents an important cause of severe neurological deficits that span the individual's lifetime, including delayed mental and motor development, epilepsy and major cognitive deficits. Most strokes occurring in term births, infants and children can be caused by thromboembolism from intracranial and extracranial vessels and are associated with a variety of risk factors such as birth asphyxia, cardiac diseases, blood disorders, maternal disorders, trauma. Animal models of perinatal stroke have been developed to examine the nature and the time course of the events occurring after the ischemic insult and the possible therapeutic strategies useful in reducing ischemic damage. The present article addresses the potential pharmacological treatments targeting the inflammatory process and apoptotic cell death, with a specific emphasis on the emerging role of statins as neuroprotective agents in perinatal stroke. As a prelude, we will also review advances in our understanding on the mechanisms underlying the hypoxic-ischemic reperfusion injury in the newborn.

围产期卒中的新治疗策略。
围产期中风是导致终生严重神经功能缺陷的重要原因,包括智力和运动发育迟缓、癫痫和严重认知缺陷。大多数发生在足月出生、婴儿和儿童的中风可由颅内和颅外血管的血栓栓塞引起,并与多种危险因素有关,如出生窒息、心脏病、血液疾病、产妇疾病、创伤。围产期中风动物模型的建立是为了研究缺血性损伤后发生的事件的性质和时间过程,以及减少缺血性损伤的可能治疗策略。本文讨论了针对炎症过程和凋亡细胞死亡的潜在药物治疗,特别强调了他汀类药物在围产期中风中作为神经保护剂的新作用。作为开场白,我们还将回顾我们对新生儿缺氧缺血再灌注损伤机制的理解进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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