Genetic elements carrying macrolide efflux genes in streptococci.

Current drug targets. Infectious disorders Pub Date : 2004-09-01 DOI:10.2174/1568005043340641

Gianni Pozzi, Francesco Iannelli, Marco R Oggioni, Maria Santagati, Stefania Stefani

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引用次数: 37

Abstract

Type M resistance to macrolides in Streptococcus pyogenes and Streptococcus pneumoniae is associated to the presence of macrolide efflux genes (mef). These genes are carried by 3 very conserved chromosomal genetic elements: (i) "mega", 5.5 kb, typical of S. pneumoniae, carries mef(E), can insert at different sites in the bacterial chromosome and in other genetic elements, does not have genes encoding putative recombinases or transposases, and it is not conjugative; (ii) Tn1207.3, 54, 52 kb, typical of S. pyogenes, carries mef(A), it integrates at a single specific site in the bacterial chromosome, carries 3 ORFs encoding for putative recombinases, it is transferred by conjugation among different streptococcal species, and its genome resembles that of a bacteriophage; (iii) Tn1207.1, 7.2 kb, is a defective form of Tn1207.3 found in a clonal population of S. pneumoniae, it carries mef(A), it integrates at a single specific site in the bacterial chromosome (the same of Tn1207.3), and it is not conjugative.

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链球菌中携带大环内酯外排基因的遗传元件。

化脓性链球菌和肺炎链球菌对大环内酯类药物的M型耐药性与大环内酯类药物外排基因(mef)的存在有关。这些基因由3个非常保守的染色体遗传元件携带:(1)“mega”，5.5 kb，典型的肺炎链球菌，携带mef(E)，可以插入细菌染色体的不同位置和其他遗传元件，不具有编码推定的重组酶或转座酶的基因，并且不具有共轭性;(ii)典型的化脓性链球菌Tn1207.3, 54,52 kb，携带mef(A)，它整合在细菌染色体的单个特定位点，携带3个编码假定重组酶的orf，它通过接合在不同链球菌物种之间转移，其基因组与噬菌体相似;(iii) Tn1207.1, 7.2 kb，是在肺炎链球菌克隆群体中发现的Tn1207.3的缺陷形式，它携带mef(a)，它整合在细菌染色体的单个特定位点(与Tn1207.3相同)，并且它不是接合的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current drug targets. Infectious disorders

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